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Ferreira et al., Mem Inst Oswaldo Cruz 2012
(Chronic Disease...) :
We demonstrate that stimulation with SEA induced prominent lymphocyte proliferation and high levels of tumour necrosis factor (TNF)-a, interleukin (IL)-4 and IL-10 secretion in both OST and non infected individuals ( NI )
Hobeika et al., Biochem Biophys Res Commun 1996
:
A synthetic peptide of this region, SEA ( 121-149 ), blocks SEA binding to class II MHC molecules and induces interleukin-1 and tumor necrosis factor production in monocytes