UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to E2F4

E2F2 — E2F4

Pathways - manually collected, often from reviews:

FastForward regulation: E2F4 → E2F2 (transcriptional regulation, unknown) Sears et al., Mol Cell Biol 1997 *
Evidence: DNABINDING
NCI Pathway Database E2F transcription factor network: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → E2F4/DP2/p107-p130 complex (E2F4-RBL2_RBL1-TFDP2) (transcription, activates)
Takahashi et al., Genes Dev 2000, Zhu et al., EMBO J 2004, Hurford et al., Genes Dev 1997
Evidence: mutant phenotype, reporter gene, physical interaction
NCI Pathway Database E2F transcription factor network: CEBPA/BRM/RB1/E2F4 complex (CEBPA-SMARCA2-RB1-E2F4) → E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) (transcription, inhibits)
Iakova et al., Cell 2003, Hiebert et al., Proc Natl Acad Sci U S A 1989
Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
STRING interaction: E2F2 — E2F4 (interaction, mapped from kegg_pathways)
STRING interaction: E2F4 — E2F2 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Smith et al., J Biol Chem 2000 : The postconfluent dividing cells share features with cells that normally exit the cell cycle ; p27 ( kip1 ) is increased , p21 ( waf1/cip1 ) is decreased, free E2F DNA binding activity is reduced, and E2F4 is primarily nuclear
Li et al., Mol Cell Biol 2003 : Our results indicate specific roles for E2F1 and E2F2 in the induction of E2F target genes, which contribute to efficient expansion and maturation of hematopoietic progenitor cells
Dingar et al., J Mol Cell Cardiol 2012 : As analyzed by chromatin immunoprecipitation, the E2F4-p130-repressor directly blocks transcription of essential apoptosis related genes, E2F1 , Apaf-1, and p73a through recruitment of histone deacetylase 1 (HDAC1)