◀ Back to FGF21

FGF21 — SLC2A1

Text-mined interactions from Literome

Suzuki et al., Mol Endocrinol 2008 : In 3T3-L1 adipocytes, up-regulation of glucose transporter (GLUT) expression by FGF21 was associated with expression of betaKlotho, which was absent in undifferentiated 3T3-L1 fibroblasts
Li et al., Mol Cell Endocrinol 2012 : In 3T3-L1 adipocytes, the up-regulation of FGF-21markedly increased GUR, decreased intracellular triglyceride ( TG ) content, up-regulated ß-klotho, FGFR1, GLUT-1 , IRS-1, ATGL, HSL, and ap2 mRNA expressions ( p < 0.05 )
Ge et al., J Biol Chem 2011 : Quantitative real-time PCR and a luciferase reporter assay showed that FGF21 induced GLUT1 expression through transcriptional activation ... The truncation of the GLUT1 promoter from -3145 to -3105 bp, which contains two highly conserved serum response element ( SRE ) and E-Twenty Six ( ETS ) binding motif, dramatically decreased FGF21 induced promoter activity of the GLUT1 gene ... The siRNA mediated knockdown of either SRF or Elk-1 resulted in a marked attenuation in FGF21 induced GLUT1 expression and glucose uptake in adipocytes ... In conclusion, FGF21 induces GLUT1 expression and glucose uptake through sequential activation of ERK1/2 and SRF/Elk-1, which in turn triggers the transcriptional activation of GLUT1 in adipocytes
Takagi et al., Invest Ophthalmol Vis Sci 1994 : Serum, fibroblast growth factor , platelet derived growth factor, and insulin-like growth factor-1 did not increase GLUT-1 gene expression to an appreciable level, as shown by Northern blot analysis