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Qin et al., J Pharmacol Exp Ther 2001
:
Prostaglandin A ( 1 ) ( PGA1 ) reportedly inhibits NF-kappaB activation and induces expression of heat shock proteins ... PGA1 ( 5-80 nmol ) significantly inhibited QA-induced NF-kappaB activation by blocking inhibitory kappaB-alpha degradation but had no effect on activator protein-1 binding activity
He et al., Acta Pharmacol Sin 2002
:
PGA1 can inhibit rat cardiac microvascular endothelial cell apoptosis by inhibiting activity of NF-kappaB Wang et al., J Neurochem 2002
(Neuroblastoma) :
PGA1 blocked the rotenone induced nuclear translocation of NF-kappaB and attenuated, but did not abolish, the caspase-3 elevation
Mandal et al., J Immunol 2005
(Inflammation) :
Most interestingly, an anti-inflammatory PG ( PGA1 ) suppresses NF-kappaB activation and inhibits COX-2 gene expression