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CASP1 — IRF1

Text-mined interactions from Literome

Sancéau et al., Oncogene 2000 (Sarcoma, Ewing) : IFN-beta induces serine phosphorylation of Stat-1 in Ewing 's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7
Fantuzzi et al., Eur J Immunol 2001 : In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP ... In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP
Fulda et al., Oncogene 2002 (Neoplasms) : Moreover, ectopic expression of IRF1 induced caspase-8 expression thereby sensitizing cells for TRAIL-, APO1- or doxorubicin induced apoptosis
Detjen et al., Int J Oncol 2002 (Carcinoma, Neuroendocrine...) : Taken together our results characterize IFN-gamma as a potent proapoptotic stimulus in a subset of gastrointestinal NETs and suggest an IRF-1 mediated induction of caspase-1 as a relevant underlying mechanism
Suk et al., J Pharmacol Exp Ther 2003 : Moreover, baicalein inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activity in BV-2 cells without affecting caspase-11 activation, interferon regulatory factor-1 induction , or signal transducer and activator of transcription-1 phosphorylation ... Moreover, baicalein inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activity in BV-2 cells without affecting caspase-11 activation, interferon regulatory factor-1 induction , or signal transducer and activator of transcription-1 phosphorylation
Ruiz-Ruiz et al., J Biol Chem 2004 (Breast Neoplasms) : The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1
Bowie et al., Oncogene 2004 : Treatment of acutely damaged HMEC-E6 cells with 1.0 microM Tam resulted in recruitment of CBP to the gamma-IFN activated sequence element of the IRF-1 promoter, induction of IRF-1 , and sequential activation of caspase-1 and -3
De Ambrosis et al., Int J Cancer 2007 (Neuroblastoma) : Moreover, RNA interference experiments also supported the involvement of IRF-1 and IRF-2 in constitutive caspase-8 expression in NB cells
Stang et al., Oncogene 2007 (Breast Neoplasms) : Here we demonstrate that in MDA468 breast cancer cells, apoptosis by IFN-gamma is mediated by IRF-1 and IFN-gamma, and IRF-1 induced apoptosis is caspase mediated ... IRF-1 induction results in cleavage of caspase-8 , -3 and -7, and application of caspase inhibitors attenuate activated cleavage products
Liu et al., J Biol Chem 2012 (Disease Models, Animal...) : Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1 dependent caspase 8 activation ... Meanwhile, overexpression or knockdown of IRF-1 not only enhanced or inhibited GMC apoptosis and caspase 8 and 3 induction but also increased or decreased caspase 8 promoter activity, respectively
Tamura et al., Nature 1995 : We also show that mitogen induction of the interleukin-1 beta converting enzyme ( ICE ) gene, a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3, is IRF-1 dependent ... Ectopic overexpression of IRF-1 results in the activation of the endogenous gene for ICE and enhances the sensitivity of cells to radiation induced apoptosis
Tamura et al., Leukemia 1997 : Furthermore, we found that mitogen induction of the interleukin-1 beta converting enzyme ( Ice ) gene, a mammalian homolog of the Caenorhabditis elegans cell death gene ced-3, is also IRF-1 dependent
Takeuchi et al., J Virol 1998 : Following induction of the IRF-1 gene, ICE gene expression increased significantly, and an increase of ICE protein was observed in the RSV infected cell lysate ... These observations suggest that RSV infection of human alveolar epithelial cells induces the ICE gene and its protein as a result of increased IRF-1 induction but that the increased ICE was insufficient to cause apoptosis in the RSV infected cells