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NOS3 — NOX4

Text-mined interactions from Literome

Yang et al., J Cardiovasc Pharmacol 2000 : We conclude that estrogen increases NOx release in HCAECs, which is independent of cytosolic Ca2+ mobilization and is mediated by the upregulation of eNOS
Kobayashi et al., J Physiol Pharmacol 2001 (Stomach Ulcer) : In addition the expression of cyclooxygenase-2 and inducible nitric oxide synthase proteins increased PGE2 generation and NOx secretion in the ulcerated stomach were suppressed by FR167653
Endres et al., Stroke 2004 (Substance Withdrawal Syndrome) : Rho negatively regulates endothelial nitric oxide synthase and Rac contributes to NAD ( P ) H-oxidase activation and superoxide production
Rask-Madsen et al., Arterioscler Thromb Vasc Biol 2005 (Arteriosclerosis...) : Furthermore, the review summarizes studies that implicate PKC in promoting proatherogenic mechanisms or inhibiting antiatherogenic mechanisms, including studies of endothelial dysfunction ; gene induction and activation of vascular NAD ( P ) H oxidase ; endothelial nitric oxide synthase expression and function ; endothelin-1 expression ; growth, migration, and apoptosis of vascular smooth muscle cells ; induction of adhesion molecules ; and oxidized low-density lipoprotein uptake by monocyte derived macrophages
Polytarchou et al., Eur J Pharmacol 2005 : Superoxide dismutase ( SOD ), tempol ( membrane permeable SOD mimetic ) and the NADPH oxidase inhibitors, 4- ( 2-aminoethyl ) -benzenesulfonyl fluoride and apocynin, but not allopurinol, inhibited HUVEC proliferation and migration, as well as activity of endothelial NOS (eNOS)
Basu et al., Crit Rev Microbiol 2005 : Perturbation of macrophage surface with different bacterial pathogens leads to activate general signal transduction pathways of macrophages, including activation of NADPH oxidase , nitric oxide synthase , and so on
Hu et al., Am J Hypertens 2006 (Hypertension) : In male SD rats, apocynin but not l-arginine prevented and reversed Dex-hypertension, suggesting that NAD ( P ) H oxidase mediated superoxide production but not endothelial nitric oxide synthase uncoupling is important in Dex-hypertension
Oak et al., Diabetes 2007 (Diabetes Mellitus, Experimental...) : Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice
Zhang et al., Arterioscler Thromb Vasc Biol 2008 : Paradoxical activation of endothelial nitric oxide synthase by NADPH oxidase
Besler et al., Expert Rev Cardiovasc Ther 2008 (Atherosclerosis...) : The underlying mechanisms remain largely to be defined ; however, they likely include activation of the PI3-kinase/Akt pathway and endothelial nitric oxide synthase , as well as inhibition of NAD ( P ) H oxidase activity of progenitor cells
Signorello et al., Biochim Biophys Acta 2009 : Thus NO, cGMP and superoxide anion level, the phosphorylation status of nitric oxide synthase , the protein kinase C ( PKC ), and NADPH oxidase activation were measured
McCarty et al., Med Hypotheses 2010 (Atrial Fibrillation...) : Nox2- and Nox4 dependent NADPH oxidase activity appears to be a major source of this oxidative stress, and oxidants can induce conformational changes in xanthine dehydrogenase, nitric oxide synthase , and the mitochondrial respiratory chain which increase their capacity to generate superoxide as well
Ikeda et al., Free Radic Biol Med 2010 : This increase was significantly inhibited by N ( ? ) -nitro-l-arginine ( nitric oxide synthase inhibitor ) and diphenyleneiodonium chloride ( NADPH oxidase inhibitor )
Zanette et al., Toxicol In Vitro 2011 (Necrosis) : Apocynin, NADPH-oxidase inhibitor, or N ( G ) -monomethyl-L-argynine, nitric oxide synthase inhibitor , did not prevent NPs induced reduction of cell viability
Jarajapu et al., Invest Ophthalmol Vis Sci 2011 (Diabetic Retinopathy...) : The authors tested the hypothesis that either increasing eNOS expression or inhibiting NADPH oxidase would restore the reparative function in diabetic EPCs
Craige et al., Circulation 2011 (Ischemia) : Because endothelial nitric oxide synthase (eNOS) is involved in endothelial angiogenic responses and eNOS is activated by reactive oxygen species, we probed the effect of Nox4 on eNOS
Schuhmacher et al., Diabetes 2011 (Diabetes Mellitus, Experimental...) : Diabetes is associated with vascular oxidative stress, activation of NADPH oxidase , and uncoupling of nitric oxide ( NO ) synthase ( endothelial NO synthase [eNOS ] )
Shuttleworth et al., J Auton Nerv Syst 1995 : NOx release was inhibited by an inhibitor of nitric oxide synthase activity ( N ( G ) -monomethyl-L-arginine ) or by reduction in extracellular Ca2+ concentration