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CASP1 — CASP9
Text-mined interactions from Literome
de Bilbao et al., Neuroscience 2000
(Facial Nerve Injuries) :
Similar results were obtained in interleukin-1 beta converting enzyme-deficient and wild-type mice, indicating that the
interleukin-1 beta converting enzyme may not be
required for
caspase 3 activation
Robertson et al., Crit Rev Toxicol 2000
:
Caspase-9 can signal downstream and
activate pro-caspase-3 and -7
Viswanath et al., J Neurosci 2001
(Disease Models, Animal...) :
Caspase-9 activation
results in downstream
caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson 's disease ...
Caspase-9 inhibition
prevented the activation of both caspase-3 and
caspase-8 and also inhibited Bid cleavage, but not cytochrome c release
Robertson et al., Toxicology 2002
(Necrosis) :
Caspase-9 can signal downstream and
activate pro-caspase-3 and -7
Cuello et al., Cell Death Differ 2004
:
Caspase-9 may further
activate caspase-8 , generating an amplification loop
Yang et al., Nephron. Experimental nephrology 2004
(Necrosis) :
Here we evaluate three
caspase inhibitors : B-D-FMK ( pan caspase inhibitor ), Z-DEVDFMK ( predominantly Caspase-3 inhibitor ) and Z-VAD-FMK ( predominantly
Caspase-1 and -3
inhibitor ) to ameliorate apoptosis induced by cisplatin in rat proximal tubular ( RPT ) cells
Messerli et al., Neoplasia (New York, N.Y.) 2004
(Glioma) :
The specificity of this probe for caspase-1 is supported by various lines of evidence : 1 ) activation by purified caspase-1, but not another caspase in vitro ; 2 ) activation of the probe by infection of cells with a herpes simplex virus amplicon vector ( HGC-ICE-lacZ ) expressing a catalytically active
caspase-1-lacZ fusion protein; 3 )
inhibition of
HGC-ICE-lacZ vector induced activation of the probe by coincubation with the caspase-1 inhibitor YVAD-cmk, but not with a caspase-3 inhibitor ; and 4 ) activation of the probe following standard methods of inducing apoptosis with staurosporine, ganciclovir, or ionizing radiation in culture
Martin et al., J Biol Chem 2005
:
Caspase-9 cleaves and
activates effector caspases, predominantly
caspase-3 , resulting in the demise of the cell
Guo et al., Cell Death Differ 2006
:
Caspase-1 activation of
caspase-6 in human apoptotic neurons
Lang-Rollin et al., Apoptosis 2005
:
Caspase 9 and 3 are processed, cytochrome c is released from the mitochondria and a dominant negative form of
caspase 9
prevents death
Daher et al., Exp Dermatol 2006
:
Caspase-9-DN and zLEHD-fmk both
suppressed caspase-9 , -3, and -8 activity after UVB exposure, as well as proteolytic processing of procaspase-3 into its active form, DNA fragmentation factor 45 cleavage, and internucleosomal DNA fragmentation
Uchiyama et al., Infect Immun 2007
(Necrosis) :
Caspase-9 activation was also detected in H37Rv infected cells, but H37Ra never
induced such
caspase-9 activation
Zhao et al., Tohoku J Exp Med 2008
(Myocardial Infarction...) :
Caspase-9 cleaves and
activates caspase-3
Tang et al., Oncol Rep 2009
(Adenocarcinoma...) :
Caspase-9 and -3 inhibitors almost completely
suppressed HCT induced
caspase-9 and -3 activities
Shi et al., Toxicol Lett 2010
:
Caspase 9 inhibition
blocked the TNP induced activation of
caspase 3 significantly
Ohsawa et al., Proc Natl Acad Sci U S A 2010
:
Maturation of the olfactory sensory neurons by
Apaf-1/caspase-9 mediated
caspase activity ... Here, we provide unique evidence that
Apaf-1/caspase-9 mediated
caspase signaling regulates the development of olfactory sensory neurons ( OSNs ), which includes axonal projection, synapse formation, and maturation of these neurons
Fang et al., J Immunol 2011
(Disease Resistance...) :
Caspase-1 activation was partially impaired in NLRP3 ( -/- ) macrophages, whereas knockdown and knockout of AIM2
resulted in a clear decrease in
caspase-1 activation in response to S. pneumoniae
Liu et al., PloS one 2012
:
Caspase-9 inhibitor could
inhibit activation of
pro-caspase-3 , and the inhibition of the function of Apaf-1 with FSBA blocked apoptosis, hinting that Apaf-1 could be involved in Sl-1 cell apoptosis induced by AfMNPV
LaRock et al., Cell Host Microbe 2012
:
Caspase-1 activation antagonizes Yersinia survival in vivo, and consequently YopM inhibition of
caspase-1 is
required for Yersinia pathogenesis
Wang et al., Cell 1998
(Shock, Septic) :
Murine
caspase-11 , an ICE interacting protease, is
essential for the activation of
ICE ... Furthermore, we found that
pro-caspase-11 physically interacts with pro-ICE in cells, and the expression of casp-11 is
essential for activation of
ICE ... Our data suggest that
caspase-11 is a component of ICE complex and is
required for the activation of
ICE