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IL6 — ITGA5

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL6 → Complex of ITGA5-ITGB1 (increases, IL6 Activity)
  Evidence: Ligation of alpha 5 beta 1 using activating mAb JBS5 (which acts as agonist similar to FN N-terminal fragment) up-regulates the inflammatory mediators such as NO and PGE2 as well as the cytokines, IL-6 and IL-8. Furthermore, up-regulation of these proinflammatory mediators by alpha 5 beta1 integrin ligation is mediated via induction and autocrine production of IL-1 beta, because type II soluble IL-1 decoy receptor inhibits their production.

Text-mined interactions from Literome

Ohashi et al., Exp Cell Res 1995 : Up-regulation of integrin alpha 5 beta 1 expression by interleukin-6 in rabbit corneal epithelial cells ... The IL-6 induced up-regulation of integrin alpha 5 and beta 1 mRNAs was also confirmed by Northern blot analysis
Takizawa et al., Clin Exp Immunol 1995 : These results indicate that fibronectin induced production of IL-1 alpha, IL-1 beta, TNF-alpha and IL-6 from cultured monocytes is mediated predominantly by interaction of the cell binding domain of fibronectin with VLA-5 , although Mac-1 also may contribute to this effect of fibronectin