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Nurse et al., J Allergy Clin Immunol 2000 (Asthma) : PPD stimulated proliferation, IL-5 release, IFN-gamma release, and the IL-5/IFN-gamma ratio were not significantly different among the groups
Kamal et al., Clin Exp Allergy 2001 : Two ANXA1 derived peptides, Ac2-26 and AF-2 ( 5-500 microM ), were assessed for possible inhibition of PHA-and antigen induced T cell proliferation ( measured by 3H-thymidine uptake ), while Ac2-26 was assessed for inhibition of Der p-induced interleukin (IL)-5 release and PPD induced interferon-gamma (IFN-gamma) release ( measured by ELISA )
Dheenadhayalan et al., Infect Immun 2001 (Cicatrix...) : Most of the patients and controls expressed IFN-gamma de novo, and in the presence of purified protein derivative (PPD) , all of them expressed significantly higher levels of IFN-gamma , suggesting a PPD-specific recall memory
Buddle et al., Vaccine 2002 (Tuberculosis, Bovine) : Vaccination with the newly derived attenuated M. bovis strains induced strong IFN-gamma and interleukin-2 (IL-2) responses to PPD from M. bovis at 2 weeks after vaccination, while BCG vaccination induced only a weak response at this time
Laaksonen et al., Allergy 2003 (Hypersensitivity, Immediate) : PPD induced IFN-gamma mRNA expression both in allergic patients and healthy controls, whereas IFN-gamma production was induced only in healthy controls and IL-4 was not induced at all
Nonnecke et al., Int Z Vitam Ernahrungsforsch Beih 2003 : PPD induced IFN-gamma and TNF-alpha responses of cells from vaccinated calves and adults were greater than responses of autologous unstimulated cells
Weir et al., Clin Exp Immunol 2003 : Data are presented for tuberculin ( Heaf ) skin test and interferon-gamma (IFN-gamma) responses to M. tuberculosis purified protein derivative (PPD) , and IFN-gamma responses to PPDs from eight other environmental mycobacteria, measured in 424 schoolchildren ( 13-15 years of age )
Gormley et al., Vet Immunol Immunopathol 2004 (Tuberculosis, Bovine) : No significant differences were measured in the IFN-gamma responses of the reactor animals to PPD-bovine and PPD-avian for up to 65 days
Walrath et al., Am J Respir Cell Mol Biol 2005 : Further studies confirmed that baseline BAL lymphocytes of PPD positive subjects produce IFN-gamma in response to PPD , and that, compared with peripheral blood, BAL cells are preferentially enriched for PPD-specific lymphocytes
Ameni et al., Clinical and vaccine immunology : CVI 2006 (Tuberculosis, Bovine) : Our data demonstrated significantly ( all P < 0.02 ) higher IFN-gamma responses to avian PPD , bovine PPD, and the ESAT6-CFP10 protein cocktail in Holstein than in zebu cattle, while lesion severities in infected animals and tuberculin skin test responses did not differ significantly ( P > 0.05 ) between the two breeds ... Holstein cattle that were kept indoors produced significantly ( all P < 0.01 ) higher IFN-gamma levels in response to avian PPD , bovine PPD, and the ESAT6-CFP10 protein cocktail than did Holstein cattle kept in a pasture
Sugata et al., Immunology 2007 : Dimaprit, clobenpropit and clozapine, which are H4R agonists, dose-dependently blocked both PPD induced interferon-gamma and Cry j1-induced interleukin-5 production by both peripheral blood mononuclear cells ( PBMCs ) and antigen-specific T-cell lines
Jeevan et al., Clin Exp Immunol 2007 : Similarly, total, non-adherent and adherent lung digest cells from BCG vaccinated guinea pigs showed IFN-gamma and tumour necrosis factor (TNF)-alpha mRNA expression in response to ConA, lipopolysaccharide or PPD by reverse transcription-polymerase chain reaction followed by release of TNF protein but not IFN
Garrido et al., Vet Microbiol 2010 (Swine Diseases...) : These four wild boar showed a positive IFN-gamma response to the avian PPD and the real-time RT-PCR data revealed that three genes, complement component C3, IFN-gamma and RANTES, were significantly down regulated in infected animals
Kawano et al., Br J Pharmacol 1995 (Asthma) : 4. LBI also acted on normal PBMCs by downregulating the IL-4 induced IgE synthesis, phytohaemagglutin ( PHA ) - and phorbol myristate acetate ( PMA ) plus calcium ionophore (CaI) induced IL-4 secretion, and by upregulating purified protein derivatives (PPD) induced IFN-gamma production
elGhazali et al., Eur J Immunol 1993 : This was not the case with the specific antigens, where PPD preferentially induced IFN-gamma- and very few IL-4 producing cells, while TT-induced both IL-4 and IFN-gamma
Hirsch et al., Proc Natl Acad Sci U S A 1996 (Tuberculosis, Pulmonary) : Neutralizing antibody to TGF-beta normalized lymphocyte proliferation in response to PPD, partially restored blastogenesis to candidal antigen, and significantly increased PPD stimulated production of IFN-gamma in TB patients but not in contacts
Fulton et al., Infect Immun 1996 (Tuberculosis) : Functionally, IL-12 readily enhanced PPD stimulated IFN-gamma production and CD4+ T-cell mediated cytotoxicity by peripheral blood mononuclear cells from healthy tuberculin positive donors but induced less enhancement when live M. tuberculosis was the antigen
Malhotra et al., J Clin Invest 1997 (Pregnancy Complications, Infectious...) : PPD induced IFN-gamma in 30 % of Kenyan CBL ( range 79-1,896 pg/ml ), but little or no IL-4 or IL-5
Ng et al., Vet Immunol Immunopathol 1997 (Tuberculosis, Bovine) : For individual animals, positive correlations were observed between mRNA and protein levels of bovine PPD induced IFN-gamma and IL-2, although the correlations were stronger for IFN-gamma