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CDKN2C — PCNA

Text-mined interactions from Literome

Jeffrey et al., Genes Dev 2000 : The structure reveals that p18(INK4c) inhibits the CDK-cyclin complex by distorting the ATP binding site and misaligning catalytic residues
Musgrove et al., J Biol Chem 2001 (Breast Neoplasms) : Decreased cyclin expression, induction of p18(INK4c) and increased association of the CDK inhibitors p21 ( WAF1/Cip1 ) and p27 ( Kip1 ) with cyclin E-Cdk2 have been implicated in these responses
Matsuzaki et al., Oncogene 2004 : p18(INK4c) , a member of INK4 family of cyclin dependent kinase inhibitors, negatively regulates the cyclin D-cyclin dependent kinase 4/6 complexes which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product
Xu et al., J Immunol 2011 (Disease Models, Animal...) : Cyclin dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410 derived murine lupus susceptibility locus Sle2c1
Potula et al., J Immunol 2012 (Disease Models, Animal...) : Cyclin dependent kinase inhibitor Cdkn2c deficiency promotes B1a cell expansion and autoimmunity in a mouse model of lupus
Easton et al., Cancer Res 1998 (Neuroblastoma) : Such high levels of p16INK4a/p18INK4c should normally inhibit cyclin dependent kinase (CDK) 4 and 6 activities in cells containing functional pRb, delaying cell cycle progression and growth