Gene interactions and pathways from curated databases and text-mining

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CUL1 — PCNA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Jiang et al., Blood 2000 : In contrast, cyclin-E and p27 ( KIP1 ) protein levels and cdk2 activity in cells adherent to FN in the presence of IL3 or SCF were similar to those in PLL-adherent and FN-nonadherent or PLL-nonadherent cells
Nishitani et al., EMBO J 2006 : PCNA is essential for Cul4- but not Skp2 directed degradation during DNA replication and following ultraviolet-irradiation
Bhaskaran et al., Mol Cell Biol 2013 : In vitro reconstitution showed that the role of SCF ( Fbw7a ) in cyclin E degradation, rather than ubiquitylation, is to serve as a cofactor of the prolyl cis-trans isomerase Pin1 in the isomerization of a noncanonical proline-proline bond in the cyclin E phosphodegron