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CDKN1A — CKAP4
Text-mined interactions from Literome
Zeng et al., EMBO J 2002
:
Over expression of wild-type, but not deletion mutant, SSRP1 remarkably enhanced
p63gamma dependent luciferase activity, G1 arrest, apoptosis and expression of endogenous PIG3,
p21 ( Waf1/cip1 ) and MDM2 in human p53-deficient lung carcinoma H1299 cells and mouse embryonic fibroblasts
MacPartlin et al., J Biol Chem 2005
:
These results suggest that p300 regulates
p63 dependent transcription of
p21
DeYoung et al., Cancer Res 2006
(Carcinoma, Squamous Cell...) :
In normal primary human keratinocytes, we find that inhibition of endogenous
p63 by RNA interference ( RNAi )
induces p21 ( CIP1 ) expression, inhibits cell cycle progression, and ultimately promotes cellular senescence
Mitchell et al., Cell death & disease 2010
:
As p21, a transcriptional target of the p53 family, is necessary for maintaining G2/M arrest, we analyzed the
roles of p53 and
p63 in modulating IGF1 stimulated
p21 expression