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CXCL12 — FYN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FYN → CXCL12 (increases)
  Evidence: ranscriptional response of selected cellular genes in Jurkat T cells upon SDF-1 exposure. Among the genes which showed a continuous increase in their expression following SDF-1 exposure were those involved in detoxification, DNA repair, apoptosis, TCR signal transduction, cytokinesis, cell adhesion molecules, chemokine receptors, and IFN-related molecules. The effects of MEK and PI3K inhibitors (50 µM PD098059 (20 21 ) and 20 µM LY294002 (22 ), respectively) on the expression of these genes ar...
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction