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EPHB2 — UTP23

Text-mined interactions from Literome

Gao et al., J Biol Chem 1999 : ERK activation by NECA or UTP is unaffected by a tyrosine kinase inhibitor ( genistein ), attenuated by a phospholipase C inhibitor ( U73122 ), and is abolished by a MEK inhibitor ( PD098059 ) or dominant negative Ras ... Inhibition of protein kinase C ( PKC ) by GF 109203X failed to block ERK activation by NECA or UTP , however, another PKC inhibitor, Ro 31-8220, which unlike GF 109203X, can block the zeta-isoform, and prevents UTP- but not NECA induced ERK activation ... In the presence of forskolin, Ro 31-8220 loses its ability to block UTP stimulated ERK activation
Santiago-Pérez et al., J Cell Physiol 2001 (MAP Kinase Signaling System) : Accordingly, ERK1/2 phosphorylation induced by UTP was inhibited by the PI3K inhibitors, wortmannin and LY294002, and the c-src inhibitors, radicicol and PP2, but not by inhibitors of protein kinase C ( PKC )
Meshki et al., Am J Physiol Cell Physiol 2004 : ATP and UTP caused activation of p38 MAPK and ERK1/2 in human neutrophils
Morris et al., J Biol Chem 2004 (Cardiomegaly) : In marked contrast, stimulation of G ( q ) -coupled purinergic receptors with UTP caused EGF receptor phosphorylation, ERK1/2 activation, and cellular growth but minimal increases in ANP transcription
Montiel et al., Cell Physiol Biochem 2006 : ATP, 2-meSATP, UTP and UDP cause a rapid and transitory increase in the phosphorylation of MAPK/ERK
Kobayashi et al., J Pharmacol Sci 2006 (Calcium Signaling) : PD98059, a MEK ( mitogen activated protein kinase kinase ) inhibitor, and BAPTA-AM [ O, O'-bis ( 2-aminophenyl ) ethyleneglycol-N, N,N ', N'-tetraacetic acid, tetraacetoxymethyl ester ], an intracellular Ca ( 2+ ) chelator, reduced UTP induced ERK phosphorylation and IL-6 mRNA expression ... However, AG1478, an epidermal growth factor (EGF)-receptor inhibitor, partially decreased UTP induced ERK phosphorylation and IL-6 expression
Scodelaro Bilbao et al., Arch Biochem Biophys 2007 (Breast Neoplasms...) : In addition, cell stimulation with ATP, ATPgamma-S or UTP but not ADPbeta-S induced the phosphorylation of ERK1/2 , p38 and JNK1/2 mitogen activated protein kinases ( MAPKs )
Neary et al., Purinergic Signal 2005 : Consistent with opposing effects of P2Y and P2X receptors on mitogenesis, UTP stimulated a transient activation of ERK whereas BzATP stimulated a more sustained ERK signal
Luke et al., Purinergic Signal 2008 : ATP and uridine 5'-triphosphate ( UTP ) increased ERK1/2 phosphorylation potently, peaking between 5 and 15 min
Ratchford et al., J Biol Chem 2010 : The EGFR dependent stimulation of UTP induced ERK1/2 phosphorylation in HSG cells is inhibited by the adamalysin inhibitor tumor necrosis factor-alpha protease inhibitor or by small interfering RNA that selectively silences ADAM10 and ADAM17 expression, suggesting that ADAM metalloproteases are required for P2Y(2)R mediated activation of the EGFR
Faure et al., J Cell Sci 2012 (MAP Kinase Signaling System) : Using a keratinocyte cell line expressing an inducible form of the Raf kinase, we show that UTP inhibits the EGF induced ERK1/2 pathway activation downstream of Raf