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MMP9 — TLR3
Text-mined interactions from Literome
West et al., J Cell Biol 2008
:
Surprisingly,
MMP inhibitors
block TLR signaling induced podosome disassembly, although stimulated endocytosis is unaffected, which demonstrates that the two phenomena are not obligatorily coupled
Lee et al., Exp Dermatol 2010
:
These findings demonstrate that the activation of TLR2,
TLR3 or TLR5
induces the expression of MMP-1 and
MMP-9 in human epidermal keratinocytes ... In addition, NF-kappaB or JNK mediated the MMP-1 expression induced by TLR2, TLR3 and TLR5, whereas NF-kappaB, JNK or p38 MAPK mediated the
MMP-9 expression
induced by TLR2,
TLR3 and TLR5
Merkle et al., Matrix Biol 2010
(Inflammation) :
Furthermore, a selectively
TLR3 mediated , time- and dose dependent upregulation of
MMP-9 and TIMP-1 is found, whereas MMP-2 expression is not significantly affected by TLR3 stimulation
Merkle et al., Cell Biol Int 2012
(Hepatitis C) :
TNFa significantly enhanced the
TLR3 dependent induction of
MMP-9 in human MC. Expression levels of MMP-2, TIMP-1 and TIMP-2 were not significantly affected by the activation of TLR3 or TNFa stimulation