Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
NR3C1
→
Complex of NCOA2-NR3C1
(increases, NCOA2/NR3C1 Activity)
Evidence: activated glucocorticoid receptor (GR) preferentially associated with SRC-2 (TIF-2/GRIP-1), which subsequently recruited pCAF
OpenBEL Selventa BEL large corpus:
NR3C1
→
Complex of NCOA2-SRCAP
(directlyIncreases, NCOA2/SRCAP Activity)
Monroy et al., Mol Endocrinol 2003* Evidence: SRCAP Functions with CARM-1 and GRIP-1 to Synergistically Activate GR-Mediated Transcription
OpenBEL Selventa BEL large corpus:
NR3C1
→
NCOA2
(increases, NCOA2 Activity)
Zhang et al., J Biol Chem 2004* Evidence: We found that ANCO-1 and likely its related protein ANCO-2 may represent a novel class of nuclear receptor corepressors that may inhibit transcriptional activity of NRs through interfering with the coactivator function of p160 by recruiting HDACs. We found that both ANCO-1C and the ANCO-1Ct fragment (amino acids 2597-2663) bound strongly to the full-length RAC3, TIF2, and SRC-1 (Fig. 1C).