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ARHGEF5 — RHOA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of RhoA activity: ARHGEF5 (ARHGEF5) → RHOA/GTP complex (RHOA) (modification, activates) Xie et al., Cell Signal 2005*, Wang et al., J Biol Chem 2009*
  Evidence: assay
• NCI Pathway Database Regulation of RhoA activity: ARHGEF5 (ARHGEF5) → RHOA/GDP complex (RHOA) (modification, activates) Xie et al., Cell Signal 2005*, Wang et al., J Biol Chem 2009*
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: RHOA — ARHGEF5 (physical association, enzymatic study) Snyder et al., Nat Struct Biol 2002*

Text-mined interactions from Literome

Debily et al., Hum Mol Genet 2004 (Breast Neoplasms...) : This pattern suggests that ARHGEF5/TIM activates Rac1, Cdc42 or RhoG rather than RhoA , as previously demonstrated in in vitro guanine nucleotide exchange assays
Wang et al., J Biol Chem 2009 (Asthma) : Arhgef5 can strongly activate RhoA and RhoB and weakly RhoC and RhoG, but not Rac1, RhoQ, RhoD, or RhoV, in transfected human embryonic kidney 293 cells ... In addition, Gbetagamma interacts with Arhgef5 and can stimulate Arhgef5 mediated activation of RhoA in an in vitro assay