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PAM — TNF

Text-mined interactions from Literome

Jovasevic et al., J Immunol 2001 (Plasmacytoma) : IFN-beta protein in turn was found to be important for the L-PAM induced up-regulation of TNF-alpha expression, as neutralization of IFN-beta inhibited the L-PAM induced up-regulation of TNF-alpha mRNA expression in MOPC-315 tumor cells ... Thus, the IFN-beta gene is an early response gene that is activated in response to L-PAM via a pathway that involves reactive oxygen species, and IFN-beta in turn plays an important role in L-PAM induced TNF-alpha up-regulation
Belge et al., J Immunol 2002 (Inflammation) : The median fluorescence intensity for Toll-like receptor 2 cell surface protein was found 2-fold higher on CD14 ( + ) CD16 ( + ) DR ( ++ ) monocytes, which may explain, in part, the higher Pam3Cys induced TNF production by these cells ... When analyzing secretion of TNF protein into the supernatant in PBMCs after depletion of CD16 ( + ) monocytes we found a reduction of LPS induced TNF by 28 % but Pam3Cys induced TNF was reduced by 64 %
Kumar et al., Microbes Infect 2006 : The treatment of HUCL cells with TLR2 neutralizing antibody resulted in a significant decrease in Pam3Cys induced hBD2 production as well as IL-6, IL-8, and TNF-alpha secretion
Han et al., J Immunol 2006 (Gram-Positive Bacterial Infections) : LTA and Pam3CSK4 induced the production of both TNF-alpha and NO
Paul-Clark et al., Br J Pharmacol 2006 : In contrast, S. aureus ( TLR2/TLR1/TLR6 ) or Pam ( 3 ) CSK4 ( TLR2/TLR1 ), or FSL-1 and LTA ( TLR2/TLR6 ) induced TNFalpha without an effect on NO. 3
Adib-Conquy et al., Crit Care Med 2006 (Heart Arrest...) : In sepsis, tumor necrosis factor production in response to lipopolysaccharide and Pam3CysSK4 was reduced, whereas interleukin-10 production was enhanced ... Monocytes from RCA patients showed a reduced production of tumor necrosis factor in response to lipopolysaccharide but neither to Pam3CysSK4 nor to heat killed bacteria
Geisel et al., J Immunol 2007 : Stimulation of naive mouse dendritic cells ( DC ) with LPS or Pam ( 3 ) CSK ( 4 ) ( P3C ) induces production of TNF-alpha via TLR4- or TLR2 signaling
Hirata et al., Mol Immunol 2008 : However, Pam3CSK4 synergistically enhanced upLPS induced DC production of IL-10 but neither IL-12 p40 nor TNF-alpha
Juarez et al., Respir Res 2010 (Tuberculosis) : Corresponding with the reduced surface and mRNA expression of TLR2, Pam3Cys induced lower production of TNF-alpha , IL-1beta and IL-6 in bronchoalveolar cells than in monocytes
Wu et al., Clinical and vaccine immunology : CVI 2010 : Glucose based peritoneal dialysis fluids suppressed the expression of TLR2 and TLR4 proteins in HPMCs. Challenge of cells with either Pam3CSK4 or LPS resulted in impaired TNF-alpha and IL-1beta production
Hauber et al., BMC pulmonary medicine 2010 : Both LPS and PAM3 significantly increased MIP-2 and TNFalpha mRNA expression compared to sham challenge ( P < 0.05 )
Chen et al., Dig Dis Sci 2011 (Salmonella Infections) : IAP-KO whole-blood stimulation with LPS and Pam-3-Cys resulted in increased IL-6 and tumor necrosis factor (TNF)-alpha secretion compared with WT
Li et al., Inflammation 2012 (Endotoxemia) : We found that in vitro LPS and Pam3CSK4 induced TNF-a , and IL-6 production are decreased in macrophages from GS/GS mice compared with WT mice ( p? < ?0.05 )
Tan et al., Mol Pharm 2012 (Inflammation...) : In this study, we demonstrate that the Toll-like receptor-2 agonist Pam2Cys , when administered intranasally, triggers a cascade of inflammatory and innate immune signals, acting as an immunostimulant by attracting neutrophils and macrophages and inducing secretion of IL-2, IL-6, IL-10, IFN-?, MCP-1 and TNF-a
Oakes et al., Am J Respir Cell Mol Biol 2013 : We demonstrated an increased WLL cell influx, increased IL-6 and chemokine KC ( Cxcl1 ), and decreased macrophage inflammatory protein (MIP)-1a and TNF-a in response to Pam3CYS as a result of ozone pre-exposure
Beenakker et al., Aging Cell 2013 : Upon stimulation with Pam3Cys-SK4 , IL-6 ; TNF-a ; and Il-1ß were significantly positively associated with lean body mass and appendicular lean in women, but not in men
Bilyk et al., J Exp Med 1993 : In addition, experiments with a range of cytokines indicated that interleukin 4, transforming growth factor beta 1 and tumor necrosis factor alpha (TNF-alpha) exhibited weaker ( but significant ) modulatory effects on PAM , and ( in the case of TNF-alpha ) amplified the effects of GM-CSF
Suzuki et al., Kekkaku 1997 (Disease Models, Animal...) : The PAM model suggested that TNF-alpha and GM-CSF could activate PAM to restrict the intracellular growth of the bacteria, probably not through the superoxide anion release, but through the myeloperoxidasae-halide system
Kreutz et al., Immunology 1997 : The addition of serum led to an increase in LPS-, SAC- and Pam3-Cys-Ala-Gly stimulated TNF-alpha secretion, indicating that the presence of serum is critical not just for LPS stimulation ... MY4, a CD14 antibody, selectively blocked the TNF-alpha secretion induced by LPS but not by Pam3-Cys-Ala-Gly or SAC
Roilides et al., Infect Immun 1998 : Thus, TNF-alpha augments the capacity of PMNs to damage Aspergillus hyphae, possibly through enhanced oxidative mechanisms, and increases PAM phagocytic activity against conidia