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RAF1 — TNF

Text-mined interactions from Literome

Yan et al., Cancer Res 2001 (MAP Kinase Signaling System) : Furthermore, TNF-alpha induced Raf-1 threonine phosphorylation, kinase activity toward MEK1, and association with KSR are also inhibited by kiKSR expression ... Our data also show by sequential in vitro kinase assays that TNF-alpha enhances KSR phosphorylation of Raf-1 on threonine, enhancing Raf-1 kinase activity toward MAP kinase kinase
Nakayama et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : We also demonstrated that Raf1 is phosphorylated and involved in the production of TNF-alpha and tyrosine phosphorylation of PI3-K via ERK
Fushimi et al., J Cell Biochem 2007 (MAP Kinase Signaling System) : Taken together, these findings indicate that Raf-1/MEK/ERK signaling pathway plays a crucial role in the production of MMP-1 in HCS-2/8 cells in response to TNF-alpha, and that the produced PGE ( 2 ) downregulates the expression of MMP-1 by blockage of TNF-alpha induced Raf-1 activation through EP4-PGE ( 2 ) receptor activation
von Bülow et al., J Immunol 2007 (MAP Kinase Signaling System) : Zinc dependent suppression of TNF-alpha production is mediated by protein kinase A-induced inhibition of Raf-1 , I kappa B kinase beta, and NF-kappa B
Belka et al., EMBO J 1995 : Moreover, ectopic expression of the human p55 TNF-R in murine pre-B 70Z/3 cells was sufficient to confer c-raf-1-kinase activation by human TNF-alpha
Hambleton et al., J Exp Med 1995 : Using an enzyme linked immunosorbent assay for murine tumor necrosis factor alpha (TNF-alpha), we found that LPS and PMA stimulation and delta Raf-1 : ER activation induced secretion of TNF-alpha , although the amount of TNF-alpha secreted in response to delta Raf-1 : ER activation and PMA stimulation was approximately 20-fold less than that secreted in response to LPS
Westwick et al., J Biol Chem 1994 : TNF alpha also produces a small and transient increase in extracellular signal regulated kinase ( ERK ) activity and no measured increase in Raf-1 kinase activity
Reimann et al., J Immunol 1994 : A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes
Geppert et al., Mol Med 1994 : In the same cell line, dominant negative inhibitors of ras and raf-1 block LPS induced activation of the TNF promoter, as well as derepression of the translational blockade normally imposed by the TNF 3'-untranslated region
Zhang et al., Cell 1997 : TNF alpha or ceramide analogs markedly enhance KSR autophosphorylation and its ability to complex with, phosphorylate, and activate Raf-1
Müller et al., EMBO J 1998 : We have investigated mechanisms of Raf-1 regulation by TNF and its messenger ceramide in cell-free assays, insect and mammalian cell lines ... Both TNF and exogeneous C6-ceramide interfered with the mitogenic activation of Raf-1 and ERK by epidermal growth factor and down-regulated v-Src induced Raf-1 kinase activity ... TNF also induced the translocation of Raf-1 from the cytosolic to the particulate fraction, indicating that this negative regulatory cross-talk occurs at the cell membrane
McLeish et al., J Leukoc Biol 1998 : GM-CSF, but not TNF-alpha , stimulated wortmannin-sensitive activation of Raf-1