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TNF — TNFRSF10B

Pathways - manually collected, often from reviews:

• NCI Pathway Database Caspase Cascade in Apoptosis: sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• WikiPathways Apoptosis: TNF → Complex of TNFRSF21-TNFRSF1B-TNFRSF25-TRADD-TNFRSF10B-TNFRSF1A (activation)
  

Text-mined interactions from Literome

Begue et al., Gastroenterology 2006 (Disease Models, Animal...) : TNF-alpha markedly increased the expression of the proapoptotic receptor TRAIL-R2
Solarewicz-Madejek et al., Clin Exp Allergy 2009 (Asthma...) : TNF-alpha up-regulated TRAILR1 and TRAILR2 ; sFasL up-regulated TNFR2