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NGF — NTF4
Text-mined interactions from Literome
Sugimoto et al., Jpn J Cancer Res 2001
(Adrenal Gland Neoplasms...) :
Exogenous
NGF induced weak neurite outgrowth, whereas exogenous BDNF and
NT-4 / 5 induced distinct neurite outgrowth
DeCouto et al., Brain Res Mol Brain Res 2003
:
The
effects of deafferentation and exogenous
NGF on neurotrophins and
neurotrophin receptor mRNA expression in the adult superior cervical ganglion
Patz et al., Eur J Neurosci 2004
:
Here we investigated the mRNA expression level of brain derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4), NT-3 and
nerve growth factor (NGF) as well as the tyrosine receptor kinases TrkB and TrkC receptor in
response to BDNF,
NT-4 , NT-3 and NGF pulses in organotypic cortex cultures
Zhang et al., Neurosci Lett 2004
:
These results indicate that
NGF can
increase the excitability of nociceptive sensory neurons through activation of the p75
neurotrophin receptor and its consequent liberation of ceramide from neuronal sphingomyelins
Pezet et al., Annu Rev Neurosci 2006
(Pain) :
NGF regulates the expression of a second
neurotrophin , brain derived neurotrophic factor (BDNF), in nociceptors
de Vries et al., Clin Exp Allergy 2006
(Asthma...) :
Direct evidence that inhibition of
NGF induced activation of
neurotrophin receptors leads to improvement of airway symptoms is lacking
Deppmann et al., Science 2008
:
NGF also
controlled expression of brain derived neurotrophic factor and
neurotrophin-4 , which, through the receptor p75, can kill neighboring neurons with low retrograde NGF-TrkA signaling whereas neurons with high NGF-TrkA signaling are protected
Fiore et al., Rev Neurosci 2009
:
NGF biological activity is
mediated by two classes of receptors : ( i ) p75
neurotrophin receptor ( p75 ( NTR ) ), a 75 kDa glycoprotein, belonging to a superfamily of cytokine receptors including TNF receptors, and ( ii ) TrkA, a transmembrane tyrosine kinase of 140 kDa
Lorentz et al., Am J Physiol Heart Circ Physiol 2010
(Arrhythmias, Cardiac...) :
NGF acts through the TrkA receptor and the p75
neurotrophin receptor ( p75 ( NTR ) ) in sympathetic neurons
Petrie et al., J Comp Neurol 2013
:
Overexpression of
nerve growth factor by murine smooth muscle cells :
Role of the p75
neurotrophin receptor on sympathetic and sensory sprouting
Arumäe et al., J Cell Biol 1993
:
NT-3,
NT-4 , and more prominently BDNF, induce neurite outgrowth from explant cultures of the E10 trigeminal ganglia but no neurites are
induced by
NGF , despite the expression of trkA
Apfel et al., Mol Cell Neurosci 1996
:
We show here that brain derived neurotrophic factor (BDNF) gene expression in dorsal root ganglia is strongly
stimulated in vivo by another
neurotrophin ,
nerve growth factor (NGF)
Zhou et al., J Comp Neurol 1996
:
Endogenous
nerve growth factor is
required for regulation of the low affinity
neurotrophin receptor ( p75 ) in sympathetic but not sensory ganglia ... The low affinity
neurotrophin receptor ( p75 ), expressed in these neurons, is
regulated by exogenous
NGF in vitro and in vivo
Iwamoto et al., J Am Acad Dermatol 1996
(Melanoma) :
The migration of Schwann cells along embryonic nerves is reportedly
regulated by the 75 kd
neurotrophin receptor ( p75NTR ) and one of its cognate ligands,
nerve growth factor (NGF)
Goldstein et al., Dev Biol 1997
:
Since trkA has not been detected in the avian sympathetic ganglia until later in development, we suggest that these early effects of exogenous
NGF may be
mediated by the low-affinity
neurotrophin receptor, p75, which is expressed from neural crest migration stages
Kontny et al., J Mol Neurosci 1997
:
On the
role of the low-affinity
neurotrophin receptor p75LNTR in
nerve growth factor induction of differentiation and AP 1 binding activity in PC12 cells
Helke et al., J Comp Neurol 1998
:
The retrograde transport of [ 125I ] NT-3 to the nodose ganglion was reduced by NT-3 and by
NGF , and the transport of [ 125I ] NGF was
reduced only by NGF, whereas the transport of [ 125I ]
NT-4 was significantly reduced by each of the neurotrophins