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NTRK2 — WT1

Text-mined interactions from Literome

Eggert et al., Klin Padiatr 2001 (Kidney Neoplasms...) : To study the role of the neurotrophin-receptor TrkB in nephroblastoma/Wilms ' Tumor ( WT ) , we determined TrkB mRNA expression by semiquantitative duplex RT-PCR in 39 primary WT. Comparison of mRNA expression levels with clinical variables was performed using Cox regression analysis
Wagner et al., Genes Dev 2005 : Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms ' tumor transcription factor Wt1 ... Activation of Wt1 in an inducible cell line significantly enhanced TrkB expression ... The critical DNA binding site for activation of the NTRK2 promoter by Wt1 was delineated by DNase I footprint analysis and electrophoretic mobility shift assay ... These findings demonstrate that transcriptional activation of the TrkB neurotrophin receptor gene by the Wilms ' tumor suppressor Wt1 is a crucial mechanism for normal vascularization of the developing heart