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IL5 — PARP1

Text-mined interactions from Literome

Yamada et al., Anticancer Res 2002 (Stomach Neoplasms) : TRF1, TRF2 and TIN2 are negative regulators of telomere length, while tankyrase and Rap1 act as positive regulators
Dantzer et al., Mol Cell Biol 2004 : In addition, our data show that PARP activity regulates the DNA binding activity of TRF2 via both a covalent heteromodification of the dimerization domain of TRF2 and a noncovalent binding of poly ( ADP-ribose ) to the myb domain of TRF2
Virág et al., Med Sci Monit 2004 (Asthma...) : The production of TNF- alpha and IL-12, but not IL-5 or IL-13, was also suppressed by PARP inhibition
Ye et al., Nat Genet 2004 : TRF1 itself can be inhibited by the poly ( ADP-ribose ) polymerase ( PARP ) activity of its interacting partner tankyrase 1, which abolishes its DNA binding activity in vitro and removes the TRF1 complex from telomeres in vivo
Datta et al., Allergy 2011 (Asthma...) : PARP-1 deficiency blocks IL-5 expression through calpain dependent degradation of STAT-6 in a murine asthma model ... To explore the mechanism by which PARP-1 regulates IL-5 production and to determine how PARP-1 inhibition blocks allergen induced eosinophilia