Gene interactions and pathways from curated databases and text-mining

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APOB — IRF6

Text-mined interactions from Literome

Vreugdenhil et al., J Clin Invest 2001 (Sepsis) : LPS binding protein circulates in association with apoB containing lipoproteins and enhances endotoxin-LDL/VLDL interaction
van Oosten et al., J Endotoxin Res 2001 : LPS significantly inhibited the binding of acetylated LDL and oxidized LDL ( two well described scavenger receptor ligands ) to isolated Kupffer and liver endothelial cells
Blázovics et al., Orv Hetil 2004 (Inflammatory Bowel Diseases) : It became known, that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and interleukin-1beta in macrophages as well as oxidized LDL modulates activation of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs
Levels et al., Infect Immun 2005 : LBP and PLTP were found to transfer LPS from HDL predominantly to low-density lipoproteins (LDL), in a time- and dose dependent manner, to induce remodeling of HDL into two subpopulations as a consequence of the LPS transfer and to enhance the steady-state association of LDL with HDL in a dose dependent fashion ... The presence of LPS on HDL further enhanced LBP dependent interactions of LDL with HDL and increased the stability of the HDL-LDL complexes
Viktorov et al., Bull Exp Biol Med 2005 : LDL and LDL -- LPS complexes were inessential for LPS binding, while LDL -- LPS binding was appreciably suppressed by LPS ( -30 % ) and LDL ( -65 % )
Park et al., Exp Mol Med 2007 (Disease Models, Animal...) : We also demonstrated that LDL blocks V. vulnificus LPS induced lethality in mice
Funk et al., Atherosclerosis 1993 (Arteriosclerosis) : LPS increased the degradation of 125I labelled LDL and the cell associated 125I labelled LDL at 37 degrees C by 1.8-fold
Tsao et al., Circulation 1997 : Promoter activity was enhanced by oxidized LDL , and LPS was inhibited by DETA-NO. Nuclear run-on assays confirmed that the effect of NO occurred at a transcriptional level
van Oosten et al., Infect Immun 1998 : LPS inhibited the binding of acetylated low-density lipoprotein ( acLDL ) to Kupffer and liver endothelial cells 40 and 55 %, respectively, and the binding of oxidized LDL ( oxLDL ) to Kupffer and liver endothelial cells 65 and 61 %, respectively