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APOB — IRF6
Text-mined interactions from Literome
Vreugdenhil et al., J Clin Invest 2001
(Sepsis) :
LPS binding protein circulates in association with apoB containing lipoproteins and
enhances endotoxin-LDL/VLDL interaction
van Oosten et al., J Endotoxin Res 2001
:
LPS significantly
inhibited the binding of acetylated
LDL and oxidized LDL ( two well described scavenger receptor ligands ) to isolated Kupffer and liver endothelial cells
Blázovics et al., Orv Hetil 2004
(Inflammatory Bowel Diseases) :
It became known, that oxidized LDL can inhibit
LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and interleukin-1beta in macrophages as well as oxidized
LDL modulates
activation of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs
Levels et al., Infect Immun 2005
:
LBP and PLTP were found to transfer LPS from HDL predominantly to low-density lipoproteins (LDL), in a time- and dose dependent manner, to induce remodeling of HDL into two subpopulations as a
consequence of the
LPS transfer and to enhance the steady-state association of
LDL with HDL in a dose dependent fashion ... The presence of
LPS on HDL further
enhanced LBP dependent interactions of
LDL with HDL and increased the stability of the HDL-LDL complexes
Viktorov et al., Bull Exp Biol Med 2005
:
LDL and LDL -- LPS complexes were inessential for LPS binding, while LDL --
LPS binding was appreciably
suppressed by LPS ( -30 % ) and
LDL ( -65 % )
Park et al., Exp Mol Med 2007
(Disease Models, Animal...) :
We also demonstrated that
LDL blocks V. vulnificus
LPS induced lethality in mice
Funk et al., Atherosclerosis 1993
(Arteriosclerosis) :
LPS increased the degradation of 125I labelled
LDL and the cell associated 125I labelled LDL at 37 degrees C by 1.8-fold
Tsao et al., Circulation 1997
:
Promoter activity was enhanced by oxidized
LDL , and
LPS was
inhibited by DETA-NO. Nuclear run-on assays confirmed that the effect of NO occurred at a transcriptional level
van Oosten et al., Infect Immun 1998
:
LPS inhibited the binding of acetylated low-density lipoprotein ( acLDL ) to Kupffer and liver endothelial cells 40 and 55 %, respectively, and the binding of oxidized
LDL ( oxLDL ) to Kupffer and liver endothelial cells 65 and 61 %, respectively