Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
HSF1
→
IL1A
(increases, IL1A Activity)
Evidence: IL-1 at a concentration of 10ng/ml induced an hsp70 response in fibroblast like synoviocytes resulting in transcriptional activation of HSF1 and enhanced hsp70 protein expression. Costimulation by TNF-alpha and IL-1 had an additive effect on both HSF1 activation and hsp70 expression. Activation of HSF1 by IL-1 was dose dependent between 5 and 15 ng/ml of cytokine added to cultures. Time kinetics revealed maximum DNA binding activity of HSF1 after 3 hours of cytokine stimulation. IL1 treated cell...
OpenBEL Selventa BEL large corpus:
HSF1
→
IL1A
(increases, IL1A Activity)
Evidence: Proinflammatory cytokines (TNF-alpha, IL-1alpha, IL-6), but not IFN-gamma or TGF-beta, induced activation of HSF1-DNA binding and hsp70 expression in cultivated SFC