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GAST — SP1
Text-mined interactions from Literome
Gerhard et al., Endocrinology 2001
:
Gastrin ( 10 ( -7 ) M )
stimulated extracellular signal related kinase1/2 phosphorylation, activated
Sp1 and cAMP-responsive element binding protein, and further induced activity of the complete rat vesicular monoamine transporter subtype 2 promoter ( -800 bp ) in gastrin/cholecystokinin B receptor cells
Bundgaard et al., FEBS Lett 1995
(Adenocarcinoma...) :
A distal
Sp1-element is
necessary for maximal activity of the human
gastrin gene promoter
Höcker et al., J Biol Chem 1998
(Stomach Neoplasms) :
Gastrin stimulation
increased cellular
Sp1 protein levels and Sp1 binding to the mCgA -88 to -77 bp element, as well as binding of CREB to its consensus motif at -71 to -64 bp. Gastrin also stimulated CREB Ser-133 phosphorylation, and abundance of cellular CREB protein levels