Gene interactions and pathways from curated databases and text-mining

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GAST — SP1

Text-mined interactions from Literome

Gerhard et al., Endocrinology 2001 : Gastrin ( 10 ( -7 ) M ) stimulated extracellular signal related kinase1/2 phosphorylation, activated Sp1 and cAMP-responsive element binding protein, and further induced activity of the complete rat vesicular monoamine transporter subtype 2 promoter ( -800 bp ) in gastrin/cholecystokinin B receptor cells
Bundgaard et al., FEBS Lett 1995 (Adenocarcinoma...) : A distal Sp1-element is necessary for maximal activity of the human gastrin gene promoter
Höcker et al., J Biol Chem 1998 (Stomach Neoplasms) : Gastrin stimulation increased cellular Sp1 protein levels and Sp1 binding to the mCgA -88 to -77 bp element, as well as binding of CREB to its consensus motif at -71 to -64 bp. Gastrin also stimulated CREB Ser-133 phosphorylation, and abundance of cellular CREB protein levels