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GTF2B — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → GTF2B (transcriptional regulation, unknown)
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Ophid Interaction: GTF2B — SP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Yeh et al., Nucleic Acids Res 2006 : The transcription factor ( TF ) Sp1 is a well-known RNA polymerase II transcription activator that binds to GC-rich recognition sites in a number of essential cellular and viral promoters
Farnham et al., Gene Expr 1991 : Sp1 activation of RNA polymerase II transcription complexes involves a heat-labile DNA binding component
Charles et al., J Cell Physiol 2009 : Our results suggest that lower HIV-1 transcription at 3 % O ( 2 ) compared to 21 % O ( 2 ) may be mediated by lower activity of CDK9/cyclin T1 and Sp1 at 3 % O ( 2 ) and that additional host cell factors such as CDK2 and NF-kappaB might be major regulators of HIV-1 transcription at low O ( 2 ) concentrations
Perkins et al., Mol Cell Biol 1994 : We have previously shown that a cooperative interaction of NF-kappa B with Sp1 is required for the efficient stimulation of HIV-1 transcription
Pagtakhan et al., Virology 1997 : We suggest that these interactions, rather than direct Tat/Sp1 binding, result in highly processive RNA polymerase II complexes and full-length viral transcripts