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KRT4 — SP1

Text-mined interactions from Literome

Opitz et al., Cancer Res 2000 : Having previously established the importance of keratin 4 in maintaining the differentiated phenotype in corneal epithelial cells, we investigated the role of Sp1 mediated transactivation of the keratin 4 promoter given the role of Sp1 in differentiation and cell cycle progression ... Sp1 transactivation of the keratin 4 promoter was diminished in cyclin D1-overexpressing cells, which may be mediated through a newly described direct interaction between Sp1 and cyclin D1 and opposed by a complex between Sp1 and pRB
Chen et al., Mol Cell Biol 1997 : Regulation of K3 keratin gene transcription by Sp1 and AP-2 in differentiating rabbit corneal epithelial cells