◀ Back to TNF

TANK — TNF

Pathways - manually collected, often from reviews:

• BioCarta tnf/stress related signaling: TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) → MAP4K2 (modification, activates)
• BioCarta tnf/stress related signaling: SODD (BAG4) → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: TRAF2 → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF) → I-TRAF (TANK) (modification, collaborate)
• BioCarta tnf/stress related signaling: TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF) → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: TRADD → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: I-TRAF (TANK) → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) → Caspase 2 (CASP2) (modification, collaborate)
• BioCarta tnf/stress related signaling: TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) → RIP (RIPK1) (modification, collaborate)

Text-mined interactions from Literome

Wang et al., Mol Cell Biol 2000 : Examination of Stat1-deficient cells showed an apparent increase in TNF-alpha induced TRADD-RIP and TRADD-TRAF2 complex formation, while interaction between TRADD and FADD was unaffected
Ivanov et al., Oncogene 2001 (Melanoma) : Altered TRAF2 signaling by a form of TRAF2, which lacks the ring finger domain ( TRAF2DeltaN ), increases activities of p38 MAPK, ATF2, and the level of TNFalpha expression
Habelhah et al., EMBO J 2002 : Tumor necrosis factor-alpha (TNF-alpha) and actinomycin D treatment results in accelerated TRAF2 degradation in wild-type mouse embryo fibroblasts ( MEFs ), as compared with Siah2 ( -/- ) cells
Funakoshi-Tago et al., J Biol Chem 2003 : Also, TNF induced association of FAK with RIP and subsequent association of RIP with TRAF2 were not observed, resulting in a failure of RIP to recruit the IKK complex in FAK-/- cells
Habelhah et al., EMBO J 2004 : Inhibition of Ubc13 expression by RNAi resulted in inhibition of TNFalpha induced TRAF2 translocation and impaired activation of JNK but not of IKK or p38
Wu et al., EMBO J 2005 : TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6 containing compartment and TRAF2 ubiquitination
Bonif et al., Biochem J 2006 : Here, we show that the pro-inflammatory cytokine TNFalpha ( tumour necrosis factor alpha ) promotes TANK [ TRAF ( TNF receptor associated factor ) family member associated NF-kappaB activator ] recruitment to the IKK complex via a newly characterized C-terminal zinc finger
Shi et al., Immunol Cell Biol 2006 : In contrast, sTNF-alpha stimulated the expression of TRAF1 and TRAF2 , recruiting both molecules onto the cell membrane poststimulation
Zhang et al., J Mol Biol 2009 : TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells
Yin et al., Biochemistry 2009 : Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2 associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling
Lee et al., J Cell Physiol 2010 (MAP Kinase Signaling System) : Furthermore, TNF-alpha induced TNFR1 and TRAF2 complex formation was revealed by immunoprecipitation using an anti-TNFR1 Ab followed by Western blot analysis against an anti-TRAF2 or anti-TNFR1 Ab
Rothe et al., Science 1995 : TRAF2 mediated activation of NF-kappa B by TNF receptor 2 and CD40