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MDM2 — RPS7
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RPS7
—
MDM2
(physical association, affinity chromatography technology)
Gao et al., Nucleic Acids Res 2013*
-
IRef Biogrid Interaction:
RPS7
—
MDM2
(direct interaction, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Biogrid Interaction:
RPS7
—
MDM2
(physical association, affinity chromatography technology)
Zhu et al., Mol Cell 2009*
-
IRef Biogrid Interaction:
RPS7
—
MDM2
(direct interaction, pull down)
Sun et al., J Biol Chem 2011*
-
IRef Biogrid Interaction:
RPS7
—
MDM2
(direct interaction, pull down)
Chen et al., Oncogene 2007*
-
IRef Biogrid Interaction:
RPS7
—
MDM2
(direct interaction, two hybrid)
Chen et al., Oncogene 2007*
-
IRef Biogrid Interaction:
RPS7
—
MDM2
(physical association, affinity chromatography technology)
Chen et al., Oncogene 2007*
-
IRef Intact Interaction:
MDM2
—
RPS7
(physical association, anti bait coimmunoprecipitation)
Chen et al., Oncogene 2007*
-
IRef Intact Interaction:
MDM2
—
RPS7
(direct interaction, pull down)
Chen et al., Oncogene 2007*
-
IRef Intact Interaction:
MDM2
—
RPS7
(physical association, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
MDM2
—
RPS7
(physical association, two hybrid)
Chen et al., Oncogene 2007*
-
IRef Intact Interaction:
MDM2
—
RPS7
(physical association, anti tag coimmunoprecipitation)
Chen et al., Oncogene 2007*
-
IRef Intact Interaction:
Complex of RPS7-RPS7-MDM2-TP53-TP53-MDM2
(association, anti bait coimmunoprecipitation)
Chen et al., Oncogene 2007*
Text-mined interactions from Literome
Xiong et al., Oncogene 2011
:
Several
ribosomal proteins regulate p53 function by modulating
MDM2
Daftuar et al., PloS one 2013
:
Relevantly, a number of
RPs have been shown to bind to MDM2 and
inhibit MDM2 E3 ligase activity, leading to p53 stabilization and cell cycle arrest, thus revealing a RP-Mdm2-p53 signaling pathway that is critical for ribosome biogenesis surveillance