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Lu et al., Cancer Sci 2008 : In polarized epithelial cells, CagA also binds to PAR1b/MARK2 and inhibits the PAR1b kinase activity, thereby disrupting tight junctions and epithelial cell polarity independent of CagA tyrosine phosphorylation
Lu et al., J Biol Chem 2009 : CagA also binds and inhibits PAR1b/MARK2 , one of the four members of the PAR1 family of kinases, to elicit epithelial polarity defect
Yamahashi et al., Cell Adh Migr 2013 : Collectively, these findings indicate that CagA mediated inhibition of PAR1b promotes RhoA dependent actin-cytoskeletal rearrangement and thereby strengthens the hummingbird phenotype induced by CagA stimulated SHP2 during infection with H. pylori cagA positive strains