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CREB1 — RPS6KA3
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Hprd Interaction:
CREB1
—
RPS6KA3
(in vitro)
Harum et al., Neurology 2001*, Gudi et al., Oncogene 2000*, Xing et al., Science 1996*, Deak et al., EMBO J 1998, Du et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
CREB1
—
RPS6KA3
(in vivo)
Harum et al., Neurology 2001*, Gudi et al., Oncogene 2000*, Xing et al., Science 1996*, Deak et al., EMBO J 1998, Du et al., J Biol Chem 1998*
Text-mined interactions from Literome
Bruning et al., Proc Natl Acad Sci U S A 2000
:
Thus
Rsk-2 is
required for growth factor stimulated expression of c-Fos and transcriptional activation of Elk-1 and the serum response factor, but not for activation of
CREB or the mitogen activated protein kinase pathway in response to PDGF and IGF-1 stimulation
Huttunen et al., J Biol Chem 2002
(Neuroblastoma) :
Furthermore, inhibition of
ERK1/2-Rsk2 dependent
CREB phosphorylation efficiently inhibited up-regulation of chromogranin gene expression upon RAGE activation
Vaidyanathan et al., J Biol Chem 2003
:
We show that this interaction has functional consequences including the inhibition of
RSK2 dependent
CREB transcription
De Cesare et al., Proc Natl Acad Sci U S A 1998
:
Rsk-2 activity is
necessary for epidermal growth factor induced phosphorylation of
CREB protein and transcription of c-fos gene
Impey et al., Neuron 1998
(Calcium Signaling) :
The sequential activation of ERK and
Rsk2 by Ca2+
leads to the phosphorylation and transactivation of
CREB