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CSF2 — SOAT1
Text-mined interactions from Literome
Liva et al., Glia 1999
:
We show here that primary microglia and a microglia cell line, BV-2, have a
Jak/STAT expression pattern and
GM-CSF inducibility similar to that of monocytes and macrophages
Hackenmiller et al., Immunity 2000
(Immunologic Deficiency Syndromes) :
Live born c-fes-/- mice exhibit lymphoid/myeloid homeostasis defects, compromised innate immunity, and increased
Stat activation in
response to
GM-CSF and IL-6 signaling
Bovolenta et al., Blood 2002
(Leukemia, Erythroblastic, Acute) :
Neutralization experiments indicated that
GM-CSF and IFN-gamma, but not SCF, were
responsible for HTLV-2 induced
STAT activation, whereas anti-GM-CSF antibodies greatly inhibited TF-1 cell proliferation
Dhar-Mascareno et al., Biochem Biophys Res Commun 2005
:
p85 binding site on the alphaGMR was essential to induce
GM-CSF receptor
dependent Stat activation
Lin et al., Arthritis Rheum 2010
(Arthritis, Experimental) :
In vitro, WYE-151650 potently suppressed IL-2 induced STAT-5 phosphorylation and cell proliferation, while exhibiting 10-29-fold less activity against JAK-3 independent IL-6- or
GM-CSF induced
STAT phosphorylation
Seidel et al., Proc Natl Acad Sci U S A 1995
(Carcinoma, Hepatocellular...) :
We have systematically examined the effects of the spacing between the TT and AA core half sites on the binding of the
STAT complexes
activated by IFN-gamma, interleukin (IL) 6, granulocyte-macrophage
colony stimulating factor , and IL-4
de Koning et al., Blood 1996
:
Electrophoretic mobility shift assays with STAT binding oligonucleotides ( m67 ) showed that activation of WT
G-CSF-R induces three distinct
STAT complexes, namely STAT3 homodimers, STAT1-STAT3 heterodimers, and STAT1 homodimers
Shimoda et al., Blood 1997
(Fibrosarcoma) :
Jak1 plays an essential role for receptor phosphorylation and
Stat activation in
response to granulocyte
colony stimulating factor
Welte et al., Eur J Immunol 1997
:
Our results implicate a specific
effect of
GM-CSF on
STAT signaling in DC which might account for the cell type-specific effect of this cytokine on development and function