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TNF — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VEGFA → TNF (increases) Ding et al., Int Immunopharmacol 2005*
  Evidence: TNF-a induced VEGF production in a time dependent manner

Text-mined interactions from Literome

Ko et al., Mol Cell Probes 1999 : We could demonstrate in HUAEC that stimulation with IL-1alpha- and TNF-alpha led to the mRNA expression of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor ( VEGF ) which are crucial in the process of angioneogenesis and atherosclerosis as well as of the granulocyte-colony stimulating factor ( G-CSF ), granulocyte macrophage-colony stimulating factor ( GM-CSF ) and stem cell factor (SCF) which are main growth factors in haematopoiesis
Bottomley et al., Clin Exp Immunol 1999 (Arthritis, Rheumatoid...) : RA PBMC VEGF production was up-regulated by TGF-beta isoforms and TNF-alpha and down-regulated by IL-4 and IL-10, with no effect observed with IL-1beta, IL-6 and IL-8 ... Antibody blocking experiments confirmed that TNF-alpha and not TGF-beta isoforms in SF increased VEGF secretion by RA PBMC
McCourt et al., Arch Surg 1999 (Neovascularization, Pathologic) : Lipopolysaccharide and TNF-alpha stimulation resulted in significantly increased release of PMN VEGF ( 532+/-49 and 484+/-80 pg/mL, respectively ; for all, presented as mean +/- SEM ) compared with control experiments ( 32+/-4 pg/mL )
Cho et al., J Immunol 2000 (Arthritis, Rheumatoid) : Stimulation of FLS with TNF-alpha , IL-1beta, and TGF-beta increased VEGF production by 1.6-, 2.0-, and 5.2-fold, respectively, and displayed an additive effect on the production of VEGF by CD40L
Chung et al., Placenta 2000 : Culture of a first trimester trophoblast cell line ( HTR-8/SVneo ), in the presence of either TNF-alpha or TGF-beta1, resulted in the expression of significant levels of VEGF in culture ... These results suggest that both TNF-alpha and TGF-beta1 may regulate the production of VEGF in early gestational trophoblasts and may therefore serve to modulate placental vascular permeability and angiogenesis that are necessary for embryo implantation and placentation
Oyama et al., J Periodontol 2000 : Effects of roxithromycin on tumor necrosis factor-alpha induced vascular endothelial growth factor expression in human periodontal ligament cells in culture ... In the present study, we examined the effects of RXM on tumor necrosis factor (TNF)-alpha induced vascular endothelial growth factor ( VEGF ) in human periodontal ligament (HPDL) cells ... These results indicate that TNF-alpha , one of the proinflammatory cytokines implicated in the pathogenesis of periodontitis, induces excess induction of VEGF in HPDL, which may account for increased angiogenesis in periodontitis lesions ... Interestingly, the antibiotic roxithromycin inhibits TNF mediated VEGF induction, suggesting its possible therapeutic utility in periodontitis and other chronic inflammatory conditions involving VEGF induction
Feldmann et al., Annu Rev Immunol 2001 (Arthritis, Rheumatoid...) : Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab, a chimeric anti-TNF alpha monoclonal antibody ( mAB ), has provided evidence that TNF regulates IL-6, IL-8, MCP-1, and VEGF production, recruitment of immune and inflammatory cells into joints, angiogenesis, and reduction of blood levels of matrix metalloproteinases-1 and -3
Dikov et al., Cancer Res 2001 : Using supershift electrophoretic mobility shift analysis, we found that although tumor necrosis factor alpha (TNF-alpha) induced the nuclear translocation and DNA binding of p65 containing complexes, VEGF alone induced nuclear translocation and DNA binding of the complexes containing RelB ... However, although TNF-alpha induced rapid activation of IkappaB kinase (IKK) as expected, this activity was substantially reduced in the presence of VEGF
Khanna et al., Free Radic Biol Med 2001 : Pretreatment of HaCaT keratinocytes with GSPE upregulated both hydrogen peroxide as well as TNF-alpha induced VEGF expression and release
Nakagami et al., Arterioscler Thromb Vasc Biol 2002 : In addition, TNF-alpha attenuated vascular endothelial growth factor- and epidermal growth factor induced extracellular signal regulated kinase phosphorylation, whereas overexpression of dominant negative SHP-1 prevented this inhibitory effect of TNF-alpha
Haro et al., J Orthop Res 2002 (Intervertebral Disc Displacement...) : Tumor necrosis factor alpha (TNF-alpha) was required for this induction of VEGF
Khanna et al., Free Radic Biol Med 2002 (Wounds, Stab) : Previously we have reported that a grape seed proanthycyanidin extract containing 5000 ppm resveratrol ( GSPE ) potently upregulates oxidant and tumor necrosis factor-alpha inducible VEGF expression in human keratinocytes ( Free Radic
Hitchon et al., Arthritis Rheum 2002 (Anoxia...) : VEGF production was potently induced by TGFbeta, and to a lesser extent by IL-1beta and TNF , and was further augmented by hypoxia
Choi et al., Am J Reprod Immunol 2002 : These results suggest that IL-1beta, IFN-gamma, and TNF-alpha may regulate the production of VEGF in early gestational trophoblasts
Wang et al., Cancer 2002 (Carcinoma...) : TNF-alpha also induced increased thyroglobulin secretion and reduced VEGF secretion by anaplastic tumor cells
Roy et al., Free radical research 2002 (Neovascularization, Pathologic) : Each of the berry samples studied significantly inhibited both H2O2 as well as TNF alpha induced VEGF expression by the human keratinocytes
Koyama et al., Eur Respir J 2002 : Interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha augmented the release of VEGF in a time- and dose dependent manner
Kosmadaki et al., FASEB J 2003 (Carcinoma, Squamous Cell) : We investigated whether blocking TNF-alpha binding to its receptors would inhibit UV-induced VEGF expression and secretion in the keratinocyte derived line SCC-12F ... Also as expected, TNF-alpha induced VEGF expression and secretion in a dose dependent manner ... Addition of a hexapeptide ( Ac-KWIIVW-NH2 ), known to block TNF-alpha binding to its receptors, abrogated this TNF-alpha effect on VEGF mRNA induction
Alexandrakis et al., Ann Hematol 2003 (Multiple Myeloma...) : IL-6 and tumor necrosis factor-alpha (TNF-alpha) are involved in the secretion of VEGF by IL-6r expressing myeloma cells
Wise et al., Arch Oral Biol 2003 : TNF-alpha itself enhanced monocyte chemotactic protein 1 (MCP-1) and vascular endothelial growth factor ( VEGF ) gene expression
Collen et al., Angiogenesis 1998 : Endothelial cells were stimulated with a growth factor [basic fibroblast growth factor ( bFGF ) and vascular endothelial growth factor ( VEGF ) 165 ] and a cytokine [tumor necrosis factor (TNF)-alpha ] to induce the u-PA/u-PA receptor dependent formation of capillary-like tubular structures
Imagawa et al., Respiration 2004 (Sleep Apnea Syndromes...) : To assess the involvement of IL-6 and TNF-alpha in VEGF increases in patients with severe OSAHS, serum levels of IL-6 and TNF-alpha were determined in patients with severe OSAHS ( n=110 ) and compared to those of controls ( n=45 ) using an enzyme linked immunosorbent assay
Sugano et al., Circulation 2004 (Ischemia) : In a rat model of hindlimb ischemia, VEGF increased but activation of KDR/flk-1 was suppressed , possibly by TNF-alpha , which might impair angiogenesis
Bagchi et al., Biochemistry (Mosc) 2004 (Hemangioma) : OptiBerry significantly inhibited both H2O2- and TNF-alpha induced VEGF ( Vascular Endothelial Growth Factor ) expression by human keratinocytes
Pufe et al., J Pathol 2004 (Osteoarthritis) : Furthermore, VEGF induced IL-1beta, IL-6, TNF-alpha , and nitric oxide expression to a small extent and stimulated the proliferation of immortalized chondrocytes
Klimiuk et al., Przegl Lek 2004 (Arthritis, Rheumatoid) : Data presented in this report support the concept of the VEGF synthesis stimulation by TNF-alpha
Honorati et al., Osteoarthritis Cartilage 2004 (Arthritis, Rheumatoid...) : IL-17, IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes ... In differentiated conditions IL-1beta and TNF-alpha , but not IL-17, can inhibit the spontaneous secretion of VEGF by human OA, RA and FP chondrocytes, and IL-17 can restore the decrease in VEGF secretion caused by TNF-alpha ... IL-17, together with IL-1beta and TNF-alpha , can enhance VEGF secretion to various extents by dedifferentiated OA chondrocytes
Chu et al., J Endod 2004 (Neovascularization, Pathologic) : Both IL-1alpha and TNF-alpha induced significantly high levels of VEGF mRNA gene expression in human pulp and gingival fibroblasts ( p < 0.05 )
Yang et al., J Surg Res 2004 : Expression and regulation of neuropilins and VEGF receptors by TNF-alpha in human endothelial cells
Chang et al., Environ Health Perspect 2005 : It reached the highest level at 21 hr and returned to the basal level by 42 hr. Tumor necrosis factor-alpha was significantly elevated only at 4 hr. ufCB induced significant increases of VEGF in BAL fluid throughout the study period, with the peak increase at 16 hr
Yoo et al., J Immunol 2005 (Arthritis, Experimental) : Arginine-rich anti-vascular endothelial growth factor ( anti-VEGF ) hexapeptide inhibits collagen induced arthritis and VEGF stimulated productions of TNF-alpha and IL-6 by human monocytes ... In addition, VEGF directly increased the production of TNF-alpha and IL-6 from human PBMC ... Moreover, anti-VEGF dRK6 inhibited the VEGF induced production of TNF-alpha and IL-6 from synovial fluid mononuclear cells of RA patients and decreased serum IL-6 levels in CIA mice
Stadlmann et al., Gynecol Oncol 2005 (Ovarian Neoplasms...) : VEGF secretion in OVCA cells was also increased by IL-1beta ( 514 +/- 105 pg/10 ( 5 ) cells ; P < 0.01 ) or TNF-alpha ( 458 +/- 168 pg/10 ( 5 ) cells ; P < 0.01 ) reaching similar levels as in IL-1beta activated HPMC
Malaguarnera et al., Int Immunopharmacol 2005 : Moreover, co-stimulation of PRL with LPS caused activation of HMMs functions, enhancement of HO-1 expression and induction of VEGF release, whereas addition of PRL inhibited up-regulation of HO-1 or VEGF induced by IFN-gamma or TNF-alpha
Strunk et al., Rheumatol Int 2006 (Arthritis, Rheumatoid...) : To compare the effect of oral glucocorticoid ( GC ) therapy with the effect of intravenous anti-TNF-alpha-therapy on serum VEGF levels of patients with rheumatoid arthritis ( RA )
Ding et al., Int Immunopharmacol 2005 : The effect of ESM on TNF-alpha induced endothelial permeability and redistribution of VE-cadherin is likely due to a reduction of VEGF protein expression as a result of modulation of the ERK signaling pathway
Garbacki et al., Journal of inflammation (London, England) 2005 : This study provides evidence to support the anti-inflammatory activity of proanthocyanidins is related to an inhibition of leukocyte infiltration which can be explained at least in part by a down-regulation of endothelial adhesion molecules, ICAM-1 and VCAM-1 and that these compounds are capable of modulating TNF-alpha induced VEGF transcription
Kimura et al., Rinsho Byori 2005 (Anoxia...) : In the present study, we examined the effects of hypoxia and TNF-alpha on PAI-1, MCP-1 and VEGF expression in cultured human proximal renal tubular cells ( HPTECs )
Aggarwal et al., Mol Pharmacol 2006 (Neoplasm Metastasis) : Such TNF induced NF-kappaB regulated gene products involved in cellular proliferation [ cyclooxygenase-2 (COX-2), cyclin D1, and c-myc ], antiapoptosis [ inhibitor of apoptosis protein (IAP)1, IAP2, X-chromosome linked IAP, Bcl-2, Bcl-x ( L ), Bfl-1/A1, TNF receptor associated factor 1, and cellular Fas associated death domain protein-like interleukin-1beta converting enzyme inhibitory protein-like inhibitory protein ], and metastasis ( vascular endothelial growth factor , matrix metalloproteinase-9, and intercellular adhesion molecule-1 ) were also down-regulated by curcumin
Hayashi et al., J Obstet Gynaecol Res 2006 : The production of VEGF , bFGF and TGF-beta respectively was enhanced by both IL-1beta and TNF-alpha
Satchell et al., Kidney Int 2006 : Cells were selected, cloned, and then characterized by light and electron microscopy ( EM ), response to vascular endothelial growth factor ( VEGF ), and tumour necrosis factor (TNF)alpha , expression of endothelial markers by focused gene array, immunofluorescence and Western blotting, and formation and behaviour of monolayers
Wang et al., Pflugers Arch 2006 (Inflammation) : The adipokine secretion pattern largely paralleled cellular mRNA levels ; IL-6 ( transiently ), MCP-1, NGF and VEGF release were stimulated by TNF-alpha , with an accelerating rate of MCP-1 secretion over 24 h. TNF-alpha has rapid and substantial effects on the synthesis of key inflammation related adipokines in human adipocytes, with highly gene-specific responses
El-Obeid et al., Phytomedicine 2006 : On the protein level, melanin significantly induced TNF-alpha and IL-6 protein production and inhibited VEGF production by monocytes and PBMC
Wang et al., Am J Physiol Regul Integr Comp Physiol 2006 : Human progenitor cells from bone marrow or adipose tissue produce VEGF , HGF, and IGF-I in response to TNF by a p38 MAPK dependent mechanism ... We hypothesized that tumor necrosis factor-alpha (TNF-alpha) stimulated progenitor cell secretion of vascular endothelial growth factor ( VEGF ), hepatocyte growth factor (HGF), and insulin-like growth factor I (IGF-I) by a p38 mitogen activated protein kinase ( MAPK ) -dependent mechanism ... Secretion of VEGF , HGF, and IGF-I in hMSCs and hAPCs was significantly increased by stimulation with TNF and was associated with increased activation of p38 MAPK ... The p38 MAPK inhibitor decreased production of TNF stimulated VEGF , HGF, and IGF-I in hMSCs and hAPCs
Ogawara et al., Arthritis Res Ther 2006 : RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed, leading to complete abolishment of TNF-alpha induced up-regulation of E-selectin, ICAM-1, VCAM-1, IL-6, IL-8, VEGF-A and Tie-2
Solà-Villà et al., Kidney Int 2006 : SB 203580, a p38 mitogen activated protein kinase inhibitor, weakly inhibited the induction of VEGF by IL-1beta in a concentration dependent manner, whereas LY 294002, a phosphoinoside 3-kinase (PI3-K) inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, strongly inhibited both IL-1beta- and tumor necrosis factor-alpha induced VEGF formation in a concentration dependent manner
Crisostomo et al., J Mol Cell Cardiol 2007 (Myocardial Reperfusion Injury) : Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF, IL-6 expression : role of the 55 kDa TNF receptor ( TNFR1 )
Nasu et al., Fertil Steril 2007 : Tumor necrosis factor-alpha regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts ... Tumor necrosis factor-alpha stimulates the secretion of vascular endothelial growth factor by cultured human oviductal epithelial cells and stromal fibroblasts ... Tumor necrosis factor-alpha stimulated vascular endothelial growth factor secretion by these cells may control oviductal fluid secretion by regulating vascular permeability
Cui et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006 (Lymphoma, B-Cell) : [ Effects of triptolide and TNF-alpha on the expression of VEGF in Raji cells and on angiogenesis in ECV304 cells ] ... In order to study the relation of antitumour mechanisms of triptolide with neovascularization, the effect of triptolide and tumour necrosis factor (TNF)-alpha on the expression of vascular endothelial growth factor ( VEGF ) in Raji cell lines and their effect on angiogenesis in human umbilical vein endothelial cells ( HUVECs ) -derived cell line ECV304 were investigated ... It is concluded that the expressions of VEGF in Raji cells are increased by TNF-alpha and suppressed by triptolide
Kobayashi et al., Biol Pharm Bull 2007 (Choroidal Neovascularization...) : The CML adduct releases TNF alpha which might induce the production and release of VEGF for the abnormal choroidal neovascularization in the patients of age related macular degeneration
Oyama et al., J Periodontal Res 2007 : Recently, we reported that roxithromycin inhibits tumor necrosis factor (TNF)-alpha induced vascular endothelial growth factor expression in human periodontal ligament (HPDL) cell cultures
Cha et al., J Rheumatol 2007 (Arthritis, Rheumatoid...) : Tumor necrosis factor-alpha induces vascular endothelial growth factor-C expression in rheumatoid synoviocytes
Sato et al., Biochem Biophys Res Commun 2007 (Inflammation) : These results suggest that p38 MAPK and TNF-alpha are involved in the VEGF expression induced by HKLM in RAW264.7 cells
Bian et al., Exp Eye Res 2007 : Despite of the weak stimulation of VEGF expression by TNF-alpha or bFGF alone, co-administration of either of these two cytokines synergized the effect of TGF-beta2 on VEGF mRNA expression and protein production
Wang et al., J Mol Cell Cardiol 2007 : In response to hypoxia or TNF , MSCs produced more VEGF , which was correlated with hypoxia or TNF activated p38 MAPK and STAT3 ... The p38 MAPK inhibitor significantly decreased hypoxia induced or TNF stimulated VEGF production in WT. Additionally, STAT3 ablation neutralized hypoxia induced MSC release of VEGF
Bian et al., Invest Ophthalmol Vis Sci 2007 : Analyses of VEGF protein production and mRNA synthesis revealed that VEGF induction by thrombin plus TNF-alpha or coculture with monocytes was additive, whereas that by co-incubation with TGF-beta2 was synergistic
Koh et al., Respir Res 2007 (Pulmonary Edema...) : In addition, VEGF significantly reduced the levels of TNF-alpha- and LPS induced active caspase-3 in HPAEC lysates
Raidl et al., Cell Biochem Biophys 2007 (Pulmonary Disease, Chronic Obstructive) : Impaired TNFalpha induced VEGF expression in human airway smooth muscle cells from smokers with COPD : role of MAPkinases and histone acetylation -- effect of dexamethasone ... The effect of cigarette smoking on VEGF expression, the modulatory role of extracellular signal regulated kinase ( ERK ) -1,-2, p38mitogen activated protein kinase ( MAPK ), histone acetylation and the anti-inflammatory effect of dexamethasone on TNFalpha induced VEGF expression were examined in human airway smooth muscle cells ( HASMC ) of five non-smokers, 17 smokers without airflow limitation and 15 smokers with COPD ... TNFalpha increased VEGF expression 5.4-fold and 4.0-fold in HASMC from non-smokers and smokers without airflow limitation, respectively, but only 2.5-fold in HASMC from smokers with COPD compared with non stimulated HASMC ... Dexamethasone ( DEX ; 10 ( -12 ) -10 ( -4 ) M ) reduced TNFalpha induced phosphorylation of ERK-1/-2 and prevented TNFalpha induced VEGF generation without differences between non-smokers, smokers with and without COPD ... The data suggest that HASMC express VEGF in response to TNFalpha and that this may be reduced in HASMC of smokers with COPD in a smoking independent manner
Crisostomo et al., Am J Physiol Cell Physiol 2008 : TNF-alpha , LPS, and hypoxia significantly increased human MSC VEGF , FGF2, HGF, and IGF-1 production versus controls
Kowalczyk et al., Mol Reprod Dev 2008 : The purpose of the present study was to investigate the effects of prostaglandin ( PG ) E ( 2 ) and tumor necrosis factor (TNF) alpha on expression of vascular endothelial growth factor ( VEGF ) and its receptors, fms-like tyrosine kinase ( Flt-1 ) and fetal liver kinase-1/kinase insert domain containing receptor ( Flk-1/KDR ), in cultured porcine luteal cells
Kommineni et al., Biochem Biophys Res Commun 2008 (Corneal Neovascularization) : TNF-alpha and IL-1 induced VEGF-A secretion by corneal fibroblasts ( HCRF ) and this was inhibited significantly by IFN-gamma
Ohba et al., J Orthop Res 2009 (Intervertebral Disc Displacement) : TNF-alpha induced VEGF , resulting in neovascularization of disc tissues in a model of HD ... The goal of the current research was to investigate the precise role of TNF-alpha induced VEGF and the mechanism of angiogenesis in disc tissues ... We performed ELISAs, Western blots, and immunohistological examinations to assess the role of TNF-alpha induced VEGF using organ disc cultures with wild type, TNF receptor 1-null ( TNF-RI ( null ) ), or TNF receptor 2-null ( TNF-RII ( null ) ) mice ... Thus, TNF-alpha induced VEGF expression in disc cells primarily through the NF-kappaB pathway
Wang et al., Am J Physiol Regul Integr Comp Physiol 2008 : High-dose TGF-alpha also increased TNF-alpha stimulated release of VEGF from MSCs. MSCs exposed to TGF-alpha and/or TNF-alpha also demonstrated increased activation of PI3-K, JNK, and ERK
Li et al., Sci China C Life Sci 2002 : In addition, the effect of tumor necrosis factor-alpha (TNF-alpha) on VEGF expression was examined ... VEGF may be implicated in the CL formation and maintenance via regulating angiogenesis, and its expression is regulated by TNF-alpha
Kim et al., Biochem Pharmacol 2009 : MKK4 is a novel target for the inhibition of tumor necrosis factor-alpha induced vascular endothelial growth factor expression by myricetin ... We investigated the inhibitory effects of 3,3',4',5,5',7-hexahydroxyflavone ( myricetin ), an abundant natural flavonoid, on TNF-alpha induced VEGF upregulation and the underlying molecular mechanism ... We found that myricetin inhibited TNF-alpha induced VEGF expression in JB6 P+ mouse epidermal cells by targeting MAPK kinase 4 ( MKK4 ), as well as MEK1 ... TNF-alpha induced VEGF expression was inhibited by SP600125 and U0126, which are inhibitors of JNK and MEK, respectively
Wang et al., Surgery 2009 : Recently, we reported that tumor necrosis factor-alpha (TNF-alpha) increased the release of vascular endothelial growth factor ( VEGF ) from human MSCs and augmented transforming growth factor-alpha ( TGF-alpha ) -stimulated VEGF secretion ... TNF-alpha or TGF-alpha increased VEGF secretion in cells transfected with GAPDH or TNFR1 siRNA ... Conversely, the effects of TNF-alpha and/or TGF-alpha on MSC VEGF production were significantly decreased, and MEK/ERK activation was negated in cells transfected TNFR2 siRNA
Wang et al., Am J Physiol Cell Physiol 2009 : We reported previously that transforming growth factor-alpha ( TGF-alpha ), a putative mediator of wound healing and the injury response, increases the release of vascular endothelial growth factor ( VEGF ), augments tumor necrosis factor-alpha (TNF-alpha) stimulated VEGF production, and activates mitogen activated protein kinases and phosphatidylinositol 3-kinase (PI-3K) pathway in human MSCs
Regueira et al., Liver Int 2009 : TNF-alpha and TLR-2, -3 and -4 agonists induced the expression of vascular endothelial growth factor , which was partially abolished by the blockage of HIF-1 alpha with CTM
Meng et al., Cancer Res 2010 (Neoplasms) : Thus, the radioprotective effect of TNFalpha was mediated by TAM produced VEGF ... Our findings offer a mechanistic basis to target macrophage populations generally or TNFalpha induced macrophage VEGF specifically as tractable strategies to improve the efficacy of radiotherapy
Kaczmarek et al., Reprod Domest Anim 2010 : Thus, we have investigated whether luteinizing hormone ( LH ) and tumour necrosis factor-alpha (TNFalpha) may affect VEGF secretion by stromal cells during early pregnancy in pigs ... The TNFalpha induced secretion of VEGF by stromal cells was detected only after 24-h treatment with the highest dose used in the experiment ( 50 ng/ml ; p < 0.05 )
Lee et al., Inflammation 2011 (Breast Neoplasms...) : Expression of interleukin (IL)-6, IL-8, and tumor necrosis factor-a were substantially increased and involved in macrophage induced VEGF and MMP-9 mRNA expression in MCF-7 cells
Lee et al., J Orthop Res 2011 (Intervertebral Disc Degeneration...) : In this study, we investigated the effects of inflammatory cytokines, IL-1ß, and TNF-a , on the expression of an angiogenic factor, vascular endothelial growth factor ( VEGF ), and neurotrophic factors, nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), in human IVD degeneration ... IL-1ß and TNF-a stimulated the gene expression of VEGF , NGF, and BDNF in nucleus pulposus ( NP ) cells isolated from patient tissues
Jung et al., Cytotherapy 2011 : In addition, the levels of monocyte chemoattractant protein-1 ( MCP-1 ) and tumor necrosis factor-a (TNF-a) were decreased, and tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) and vascular endothelial growth factor ( VEGF ) levels were increased at 4 weeks in both the IM-C and IM-I groups
Moon et al., Spine (Phila Pa 1976) 2012 (Fibrosis...) : Prior macrophage exposure increased the secretion of IL-8 and VEGF in response to TNF-a/IL-1ß stimulation whereas IL-6 production was increased in response to IL-1ß
Xiao et al., International journal of molecular sciences 2011 : TNF-a Induced VEGF and MMP-9 Expression Promotes Hemorrhagic Transformation in Pituitary Adenomas
Sasi et al., Oncogene 2012 (Carcinoma, Lewis Lung...) : Blocking p75 by short-hairpin RNA in cultured LLCs led to increases in TNF mediated apoptosis, as well as decreases in the constitutive and TNF mediated expression of angiogenic growth factors ( VEGF , HGF, PLGF ), and SDF-1a receptor CXCR4
Hsieh et al., J Comp Neurol 2012 (Neuralgia) : We investigated the effects of low-level laser on the accumulation of HIF-1a, tumor necrosis factor-a (TNF-a), and interleukin-1ß (IL-1ß) in controlling neuropathic pain, as well as on the activation of vascular endothelial growth factor ( VEGF ) and nerve growth factor (NGF) in promoting functional recovery in a rat CCI model
Galvão et al., Biol Reprod 2012 : In early CL cells, TNF increased angiogenic activity ( bovine aortic endothelial cell viability ) and VEGF and VEGFR2 mRNA levels and decreased CD36 ( real-time PCR relative quantification )
Lu et al., Invest Ophthalmol Vis Sci 2012 (Corneal Neovascularization...) : Critical role of TNF-a induced macrophage VEGF and iNOS production in the experimental corneal neovascularization ... Moreover, TNF-a enhanced VEGF and iNOS expression by peritoneal macrophage from WT, but not KO mice
Yuan et al., Int J Artif Organs 2012 : TNF-a up-regulated the gene expression of VEGF , Angiopoietin-2, and Tie2 ( p < 0.05 )
Sismanopoulos et al., Allergy 2013 (Asthma...) : IL-33 augments VEGF release induced by substance P ( SP ) and tumor necrosis factor (TNF) release induced by NT
Nguyen et al., Biomed Res 2012 (Inflammation) : Results showed that exogenous VEGF upregulates expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-a mRNAs, whereas VEGF blocker partially diminishes the LPS induced expression of pro-inflammatory factors compared to the positive control group
Ferrante et al., Inflammation 2013 : Adenosine signaling suppresses the TLR dependent expression of TNF-a , IL-12, IFN-?, and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10
Lee et al., Int Immunopharmacol 2013 : VEGF expression is enhanced by TNF-a , the main pro-inflammatory cytokine in RA ... Data suggest that TNF-a induced BAFF expression and BAFF mediated VEGF expression in synovium may cooperate to maintain the capacity of such cells to protect B cells from apoptosis and the supply of nutrients and oxygen in inflammatory microenvironments
Li et al., Fertil Steril 2013 (Adenomyosis) : To investigate the action of nuclear factor ( NF ) -?B in adenomyosis and evaluate the potential therapeutic effect of andrographolide on tumor necrosis factor (TNF)-a induced expression of NF-?B mediated genes cyclooxygease-2 (COX-2), vascular endothelial growth factor ( VEGF ), and tissue factor ( TF ) in adenomyotic stromal cells
Stinco et al., Clin Exp Dermatol 2013 : Vascular endothelial growth factor ( VEGF ) is a pivotal cytokine in the pathogenesis of psoriasis, and upregulation of VEGF by tumour necrosis factor (TNF)-a and inflammatory factors causes marked alterations in the cutaneous microcirculation
Koolwijk et al., J Cell Biol 1996 (Neovascularization, Pathologic) : bFGF and VEGF165 enhanced of the u-PAR by 72 and 46 %, but TNFalpha itself also increased u-PAR in hMVEC by 30 %
Ferrer et al., J Urol 1997 (Prostatic Neoplasms) : Induction of DU-145 cells with cytokines resulted in differential stimulation whereby TNF was a potent inducer of VEGF , and IL-1 produced lesser but statistically significant increases in VEGF expression
Yoshida et al., Mol Cell Biol 1997 : Administration of a NF-kappaB antisense oligonucleotide almost completely inhibited TNF-alpha dependent IL-8 production and partially abrogated TNF-alpha dependent VEGF production, and an Sp1 antisense sequence partially inhibited TNF-alpha dependent production of VEGF
Gaudry et al., Blood 1997 : The present work shows that phorbol-12-myristate 13-acetate ( PMA ), fMet-Leu-Phe, and tumor necrosis factor-alpha (TNF-alpha) triggered a time dependent secretion of VEGF by human neutrophils
Ferrer et al., Urology 1998 (Neovascularization, Pathologic...) : Induction of DU-145 cells with cytokines resulted in differential stimulation whereby TNF was the predominant inducer of VEGF , whereas IL-1 was the predominant inducer of IL-8
Longuet-Perret et al., Br J Dermatol 1998 (Erythema) : Conversely, UVA1R ( 5 and 7 J/cm2 ) did not modify the basal level of VEGF and did not induce the secretion of TNF-alpha by keratinocytes