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SYT1 — TP53

Text-mined interactions from Literome

Gu et al., Blood 2002 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : In the presence of wild-type ( wt ) p53 , MDM2 increased p65 promoter activity by reversing p53 mediated suppression of p65
Ryan et al., Cancer Res 2004 : Here, we show that loss of p65 , a critical subunit of NF-kappaB, can cause resistance to different agents that signal death through p53
Jeong et al., J Biol Chem 2005 : A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity
Rajakangas et al., Int J Cancer 2006 (Adenoma...) : The results suggest that p65 is involved in a p53 dependent apoptotic response in the Min mouse
Dhar et al., J Biol Chem 2010 : Expression of p53 enhances nuclear levels of p65 with corresponding increase in the DNA binding activity of NF-kappaB as detected by electrophoretic mobility shift and chromatin immunoprecipitation assays
Park et al., Mol Carcinog 2012 (Colonic Neoplasms...) : HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced p53 levels and TUNEL positive apoptotic cells ; increased the levels of CD45, CD68, CD31, VEGF, P-VEGF receptor-2, iNOS, and COX-2 as well as hemoglobin content ; and increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a, P-p65 , p65, P-c-Jun, P-Akt, P-ERK1/2, P-p38, and P-SAPK/JNK
Suzuki et al., PloS one 2011 : p53 inhibits not only the catalytic activity of IKK2 presumably through the modulation of glycosylation but also p65 ( RelA ) -mediated transactivation
Li et al., BMC molecular biology 2012 (Esophageal Neoplasms) : In addition, we found that overexpression of NF-kappaB p65 could not successfully induce miR-34a expression in esophageal cancer cell lines with mutant p53 or decreased p53
Lin et al., PloS one 2012 : ER stress induced p53 expression was significantly inhibited by coincubation with the NF-?B inhibitor, Bay 11-7082 and downregulation of NF-?B p65 expression
Sun et al., Mol Cell Biol 1995 : Although a kappa B motif partially overlaps with this element and those genotoxic agents activate NF-kappa B, it does not play a major role in p53 genotoxic stress response : NF-kappa B p65 expression did not induce significant p53 promoter activation, and NF-kappa B inhibitors ( N-acetyl cysteine and I kappa B alpha ) did not inhibit genotoxic stress-inducible p53 promoter activation
Wu et al., J Biol Chem 1994 : Both p65 transactivation and TNF-alpha induction of the p53 promoter depended on an intact NF-kappa B site