Gene interactions and pathways from curated databases and text-mining

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IGF1 — MSTN

Text-mined interactions from Literome

Kamanga-Sollo et al., J Cell Physiol 2003 : Role of insulin-like growth factor binding protein ( IGFBP)-3 in TGF-beta- and GDF-8 ( myostatin ) -induced suppression of proliferation in porcine embryonic myogenic cell cultures
Shyu et al., Cardiovasc Res 2005 : The stretch induced myostatin is mediated by IGF-1 at least in part through a p38 MAP kinase and MEF2 pathway
Solomon et al., Br J Hosp Med (Lond) 2006 (Muscular Atrophy) : The potential therapeutic role of the growth hormone/insulin-like growth factor axis, androgen modulators and myostatin inhibition are discussed
Kurokawa et al., Mol Cell Biochem 2009 : IGF-I significantly increased the level of myostatin transcript in myoblasts and newly formed myotubes at 24 h, but not at 36 h
Miyake et al., Anim Sci J 2010 : The present study was conducted to examine whether MSTN affects IGF expression during early myogenesis in cattle
Garikipati et al., J Endocrinol 2012 : IGF-1 stimulated proliferation but had minimal and delayed effects on differentiation and its actions were suppressed by myostatin
Valdés et al., J Cell Physiol 2013 (Calcium Signaling) : Our results strongly suggest that IGF-1 regulates myostatin transcription through the activation of the NFAT transcription factor in an IP3 /calcium dependent manner