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CREB5 — TAT
Text-mined interactions from Literome
Zauli et al., FASEB J 2001
:
Moreover, in transient transfection experiments,
Tat inhibited transcription of
CREB promoter in a manner strictly dependent on the presence of the cAMP-responsive elements ( CRE ) in the CREB promoter
Lee et al., Cardiovasc Res 2004
:
However,
Tat did not
affect DNA binding activities of AP-1,
CREB , and STAT1
Williams et al., Experimental biology and medicine (Maywood, N.J.) 2005
(HIV Infections) :
Within 2 hrs after stimulation,
Tat increased both
CREB phosphorylation and DNA binding by 7- to 10-fold
Zhong et al., J Neurosci 2012
:
Interestingly, inhibition of the Rho cascade protected against
Tat induced upregulation of ZO-1 in the nuclei and activation of
CREB
Bell et al., J Neurochem 2013
(Anoxia...) :
Tat-NR2B9c dependent neuroprotection and
CREB phosphorylation are blocked by coapplication of CaM kinase ( KN93 and STO-609 ) or CREB ( KG-501 ) inhibitors, and by siRNA knockdown of CaMKIV
Gibellini et al., J Immunol 1998
:
Moreover, the use of plasmids encoding for GAL4-CREB fusion proteins demonstrated that Tat induction of pG4-CAT reporter gene required the CREB moiety of the GAL4-CREB fusion protein and that Ser133
CREB was
essential for
Tat activity ... Extracellular
Tat also
stimulated Ser133
CREB phosphorylation in freshly isolated PBMC ; this effect was completely blocked by either staurosporin, a broad-spectrum inhibitor of various protein kinases, or PD 98059, a specific inhibitor of mitogen activated protein kinases ( MAPK )