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HSPB3 — TP53
Text-mined interactions from Literome
Harms et al., Mol Cell Biol 2005
:
Through the use of engineered deletion mutants, we found that activation domain 2 is required for
induction of the proapoptotic target gene insulin-like growth factor binding
protein 3 ( IGFBP3 ) by
p53 and that the basic domain inhibits induction of this gene by p53
Ma et al., J Exp Clin Cancer Res 2006
(Adenocarcinoma...) :
It was also found that the absence of mutant
p53 affected the signal transduction of TGFbeta/BMP pathway mainly by up-regulating the expression of BMP superfamily cytokine growth differentiation factor 9 (GDF9), activin superfamily cytokine inhibin beta B (INHBB), smads target genes insulin-like growth factor binding
protein 3 ( IGFBP3 ) and involucrin (IVL)
Kawasaki et al., Neoplasia (New York, N.Y.) 2007
(Adenocarcinoma...) :
Insulin-like growth factor binding
protein 3 ( IGFBP3 ), which is
induced by wild-type
p53 , regulates IGF and interacts with the TGF-beta pathway