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MEG3 — TP53
Text-mined interactions from Literome
Zhou et al., J Biol Chem 2007
:
Activation of
p53 by
MEG3 non coding RNA ... Interestingly, MEG3 does not stimulate p21 ( CIP1 ) expression, suggesting that
MEG3 can
regulate the specificity of
p53 transcriptional activation ... We found that MDM2 levels were down-regulated in cells transfected with MEG3, suggesting that MDM2 suppression contributes at least in part to
p53 accumulation
induced by
MEG3
Zhang et al., Endocrinology 2010
(Pituitary Neoplasms) :
Expression of
MEG3 in tumor cells
results in growth suppression,
p53 protein increase, and activation of p53 downstream targets
Zhou et al., J Mol Endocrinol 2012
(Neoplasms...) :
MEG3 induces accumulation of
p53 ( TP53 ) protein, stimulates transcription from a p53 dependent promoter, and selectively regulates p53 target gene expression