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CRKL — EPO

Text-mined interactions from Literome

Nosaka et al., J Biol Chem 1999 (MAP Kinase Signaling System) : Here, we demonstrate that overexpression of CrkL enhances the erythropoietin (Epo)- or interleukin (IL)-3 induced activation of Elk-1 and the c-fos gene promoter activity in 32D/EpoR-Wt cells ... These data indicate that the CrkL-C3G complex plays a role in Epo- or IL-3 induced, Ras dependent activation of the Raf/ERK pathway leading to the activation of Elk-1 and the c-fos gene transcription
Arai et al., J Biol Chem 2001 : Here, we demonstrate that Epo induces binding of CrkL to the tyrosine phosphorylated EpoR and SHIP1 in 32D/EpoR-Wt cells overexpressing CrkL
Chin et al., Biochem Biophys Res Commun 1997 : Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells ... The present study demonstrates that erythropoietin (Epo) and IL-3 induce tyrosine phosphorylation of the SH2/SH3 containing adapter protein CrkL and its transient association with tyrosine phosphorylated SHP-2, Shc, and Cbl in a murine IL-3 dependent cell line, 32D, expressing the Epo receptor (EpoR)
Ozaki et al., Blood 1998 : Furthermore, interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and erythropoietin also induce Crkl-STAT5 complex formation in responding cells in a stimulation dependent manner ... These results indicate that thrombopoietin, IL-3, GM-CSF, and erythropoietin commonly induce association of STAT5 and Crkl and that the complex translocates to the nucleus and binds to DNA