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NCOR1 — SIRT1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of NCOR1-PPARG → SIRT1 (decreases, NCOR1/PPARG Activity)
  Evidence: SIRT1 represses PPAR-gamma, a key regulator of adipogenesis, by docking with its cofactors NCoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: NCOR1 — SIRT1 Picard et al., Nature 2004*
• IRef Bind_translation Interaction: NCOR1 — SIRT1 (affinity chromatography technology) Picard et al., Nature 2004*
• IRef Bind_translation Interaction: NCOR1 — SIRT1 (coimmunoprecipitation) Picard et al., Nature 2004*
• IRef Biogrid Interaction: NCOR1 — SIRT1 (direct interaction, pull down) Hisahara et al., Proc Natl Acad Sci U S A 2008*
• IRef Biogrid Interaction: NCOR1 — SIRT1 (physical association, affinity chromatography technology) Hisahara et al., Proc Natl Acad Sci U S A 2008*
• IRef Intact Interaction: NCOR1 — SIRT1 (physical association, anti bait coimmunoprecipitation) Picard et al., Nature 2004*
• IRef Ophid Interaction: NCOR1 — SIRT1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005