Bolon et al., J Cell Physiol 2007
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We propose that LPS reduces inter-endothelial electrical coupling via tyrosine-, ERK1/2-, PKA- , and PKC dependent signaling that targets Cx40
Gobejishvili et al., J Pharmacol Exp Ther 2011
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These results demonstrate for the first time that inhibition of LPS induced PDE4B2 up-regulation and increased cAMP dependent PKA activation are significant mechanisms contributing to the anti-TNF effect of SAM