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PIGR — TNF
Text-mined interactions from Literome
Takenouchi-Ohkubo et al., Immunogenetics 2000
:
Stimulation by
TNF-alpha significantly
activated the
pIgR gene promoter, as a 775-bp upstream region of the pIgR gene increased luciferase gene expression in cells treated with TNF-alpha ... These data indicated that
pIgR gene expression
induced by
TNF-alpha is transcriptionally regulated via activation of NF-kappaB
Schjerven et al., J Immunol 2001
:
The proinflammatory cytokine
TNF-alpha is a key mediator of host responses to infections, and it can
stimulate protein synthesis dependent transcriptional up-regulation of
pIgR/SC in the HT-29 intestinal adenocarcinoma cell line ... Thus, DNA elements located > 4 kb apart were found to cooperate in
TNF-alpha induced
pIgR/SC up-regulation
Schjerven et al., J Immunol 2004
(Adenocarcinoma...) :
TNF activates a proinflammatory gene repertoire in mucosal epithelial cells and also
enhances pIgR expression ... In this study we show that
TNF induced up-regulation of the human
pIgR critically depends on an NF-kappa B site and flanking sequences within a 204-bp region of the first intron in the pIgR gene, a region largely overlapping with a recently characterized IL-4-responsive enhancer
Hamada et al., Immunology 1991
:
Additional evidence of specificity of the TNF-alpha effect on the Fc gamma IBS was that
TNF-alpha did not
affect expression of the
polymeric immunoglobulin receptor ( secretory component ), whereas IFN-gamma increased it
Takenouchi-Ohkubo et al., Immunology 2008
:
These data suggest that
TNF-alpha mediated
pIgR expression is negatively regulated by ERK pathway, which is independent of NF-kappaB
Hermsen et al., Surg Infect (Larchmt) 2008
(Wounds and Injuries) :
Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)
stimulate the production of
polymeric immunoglobulin receptor (pIgR) , the protein required to transport immunoglobulin A (IgA) to mucosal surfaces
Jonker et al., J Trauma 2010
(Pneumonia, Ventilator-Associated...) :
Tumor necrosis factor (TNF)-a and interleukin (IL)-1ß
stimulate the production of
polymeric immunoglobulin receptor , the protein required to transport immunoglobulin A (IgA) to mucosal surfaces
Bruno et al., Mucosal Immunol 2011
:
Inhibition of mitogen activated protein kinases reduced the induction of IL-8, but enhanced the
induction of
pIgR by
TNF and TLR signaling