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CDK2 — MCM7

Pathways - manually collected, often from reviews:

• BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG) → ORC/CDC6/CDT1/Cyclin E/CDK2/p27 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-CCNE1-CDK2-CDKN1B) (regulation of DNA replication initiation, activates)
  
• Reactome Reaction: CDK2 → MCM7 (reaction) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999, Méndez et al., Mol Cell 2002
• Reactome Reaction: CDK2 → MCM7 (indirect_complex) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MCM7 — CDK2 (physical association, affinity chromatography technology) Neganova et al., Stem Cells 2011

Text-mined interactions from Literome

Zou et al., Mol Cell Biol 2000 : Here we show that both Cdc45p and replication protein A (RPA) bind to Mcm2p at the G ( 1 ) -S transition in an S-CDK dependent manner
Ishimi et al., J Biol Chem 2003 : Based on results that showed that the DNA helicase activity of the MCM4-6-7 complex is negatively regulated by CDK2 phosphorylation, we suggest that the phosphorylation of MCM4 in the checkpoint control inhibits DNA replication, which includes blockage of DNA fork progression, through inactivation of the MCM complex