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CUL4A — DDB1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of RFWD2-CUL4A-DDB1-RBX1-DET1 Wertz et al., Science 2004
• IRef Bind Interaction: Complex of CUL4A-DDB1-CDT1 Hu et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of RFWD2-DET1-DDB1-CUL4A Wertz et al., Science 2004
• IRef Bind Interaction: CUL4A — DDB1 Wertz et al., Science 2004
• IRef Bind Interaction: CUL4A — DDB1 Hu et al., Nat Cell Biol 2004
• IRef Bind_translation Interaction: CUL4A — DDB1 (two hybrid) Hu et al., Nat Cell Biol 2004
• IRef Bind_translation Interaction: CUL4A — DDB1 (coimmunoprecipitation) Wertz et al., Science 2004
• IRef Bind_translation Interaction: CUL4A — DDB1 (coimmunoprecipitation) Hu et al., Nat Cell Biol 2004
• IRef Biogrid Interaction: DDB1 — CUL4A (association, biochemical) Shiyanov et al., J Biol Chem 1999*
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Bennett et al., Cell 2010
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Gastaldello et al., Journal of molecular cell biology 2012
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Kanei-Ishii et al., Biochem Biophys Res Commun 2012*
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Hodgson et al., Virology 2012*
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Kulaksiz et al., Mol Cell Biol 2005
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Wu et al., PloS one 2012
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Olma et al., J Cell Sci 2009
• IRef Biogrid Interaction: DDB1 — CUL4A (colocalization, biochemical) Havugimana et al., Cell 2012
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Guerrero-Santoro et al., Cancer Res 2008*
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Angers et al., Nature 2006
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Jin et al., Mol Cell 2006
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Wang et al., Mol Cell 2006*
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Kapetanaki et al., Proc Natl Acad Sci U S A 2006*
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Matsuda et al., DNA repair 2005*
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Hu et al., Nat Cell Biol 2004
• IRef Biogrid Interaction: DDB1 — CUL4A (direct interaction, two hybrid) Hu et al., Nat Cell Biol 2004
• IRef Biogrid Interaction: DDB1 — CUL4A (direct interaction, pull down) Ahn et al., J Biol Chem 2010*
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Maddika et al., Nat Cell Biol 2009
• IRef Biogrid Interaction: DDB1 — CUL4A (association, x-ray crystallography) Fischer et al., Cell 2011*
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) Tan et al., J Virol 2007*
• IRef Biogrid Interaction: DDB1 — CUL4A (colocalization, biochemical) He et al., Genes Dev 2006
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) He et al., Genes Dev 2006
• IRef Biogrid Interaction: DDB1 — CUL4A (physical association, affinity chromatography technology) McCall et al., Mol Cell Biol 2008
• MIPS CORUM Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1): Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) complex (CUL4A-CUL4B-DDB1-DDB2-RBX1) Wang et al., Mol Cell 2006*
• MIPS CORUM Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1): Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) complex (CUL4A-DDB1-DET1-RBX1-RFWD2) Wertz et al., Science 2004
• MIPS CORUM Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1): Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) complex (CDT1-CUL4A-DDB1-RBX1) Hu et al., Nat Cell Biol 2004
• MIPS CORUM Ubiquitin E3 ligase (DDB1, CUL4A, RBX1): Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) complex (CUL4A-DDB1-RBX1) Hu et al., Nat Cell Biol 2004
• MIPS CORUM Ubiquitin E3 ligase (DDB1, CUL4A, RBX1): Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) complex (CUL4A-DDB1-RBX1) Angers et al., Nature 2006
• MIPS CORUM DDB2 complex: DDB2 complex complex (COPS2-COPS3-COPS4-COPS5-COPS6-COPS8-CUL4A-DDB1-DDB2-GPS1-RBX1-COPS7A-COPS7B) Groisman et al., Cell 2003
• MIPS CORUM CSA complex: CSA complex complex (COPS2-COPS3-COPS4-COPS5-COPS6-COPS8-CUL4A-DDB1-ERCC8-GPS1-RBX1-COPS7A-COPS7B) Groisman et al., Cell 2003
• MIPS CORUM CSA-POLIIa complex: CSA-POLIIa complex complex (COPS2-COPS3-COPS4-COPS5-COPS6-COPS8-CUL4A-DDB1-ERCC8-GPS1-POLR2A-RBX1-COPS7A-COPS7B) Groisman et al., Cell 2003
• MIPS CORUM CEN complex: CEN complex complex (BMI1-WDR11-CBX3-CBX8-CENPA-CENPB-CENPC-CENPH-CENPI-CENPK-CENPL-CENPM-CENPO-COBLL1-CUL4A-DDB1-DHX38-FBL-HSPA5-HSPA8-KIAA1429-KIF23-CENPU-NUP93-RACGAP1-RING1-RNF2-RSF1-SHCBP1-SMARCA5-SRRT-SSRP1-SUPT16H-WTAP-ZC3H13-ZFP91) Obuse et al., Genes Cells 2004
• IRef Corum Interaction: Complex of 29 proteins (association, anti tag coimmunoprecipitation) Groisman et al., Cell 2003
• IRef Corum Interaction: Complex of 11 proteins (association, mass spectrometry studies of complexes) Wertz et al., Science 2004
• IRef Corum Interaction: Complex of 75 proteins (association, chromatin immunoprecipitation assay) Obuse et al., Genes Cells 2004
• IRef Corum Interaction: Complex of 11 proteins (association, ion exchange chromatography) Wang et al., Mol Cell 2006*
• IRef Corum Interaction: Complex of 27 proteins (association, anti tag coimmunoprecipitation) Groisman et al., Cell 2003
• IRef Corum Interaction: Complex of DDB1-RBX1-CUL4A-CDT1 (association, coimmunoprecipitation) Hu et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of RBX1-CUL4A-DDB1-RBX1-CUL4A-DDB1 (association, anti tag coimmunoprecipitation) Angers et al., Nature 2006
• IRef Corum Interaction: Complex of 27 proteins (association, cosedimentation through density gradient) Groisman et al., Cell 2003
• IRef Dip Interaction: Complex of CUL4A-DDB1 (anti tag coimmunoprecipitation) Li et al., Nature structural & molecular biology 2010*
• IRef Dip Interaction: DDB1 — CUL4A (physical association, anti tag coimmunoprecipitation) Li et al., Nature structural & molecular biology 2010*
• IRef Hprd Interaction: DDB1 — CUL4A (in vivo) Wertz et al., Science 2004
• IRef Hprd Interaction: Complex of 49 proteins (in vivo) Hu et al., Genes Dev 2008
• IRef Hprd Interaction: Complex of DDB1-CUL4A-FBXW5-CUL4A-CUL4A-FBXW5-DDB1-FBXW5-DDB1 (in vivo) Hu et al., Genes Dev 2008
• IRef Hprd Interaction: Complex of 36 proteins (in vivo) Hu et al., Genes Dev 2008
• IRef Hprd Interaction: Complex of 50 proteins (in vivo) Higa et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of 22 proteins (association, tandem affinity purification) Fang et al., J Proteome Res 2008
• IRef Intact Interaction: Complex of DDB1-EED-CUL4B-CUL4A (association, anti bait coimmunoprecipitation) Higa et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of CUL4B-COPS2-DTL-COPS4-DDB1-CUL4A-COPS6 (physical association, tandem affinity purification) Hutchins et al., Science 2010
• IRef Intact Interaction: Complex of 32 proteins (physical association, tandem affinity purification) Hutchins et al., Science 2010
• IRef Intact Interaction: Complex of DDB1-DDA1-CUL4A (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 31 proteins (association, anti tag coimmunoprecipitation) Jäger et al., Nature 2012
• IRef Intact Interaction: Complex of 73 proteins (association, tandem affinity purification) Xirodimas et al., EMBO Rep 2008
• IRef Intact Interaction: Complex of DDB1-DDA1-CUL4A-VPRBP-SAMHD1 (association, tandem affinity purification) Laguette et al., Nature 2011*
• IRef Intact Interaction: Complex of CUL4A-DDB1-SAMHD1 (association, anti tag coimmunoprecipitation) Laguette et al., Nature 2011*
• IRef Intact Interaction: Complex of RBX1-DDB1-VPRBP-CUL4A (association, pull down) Kassmeier et al., EMBO J 2012
• IRef Intact Interaction: DDB1 — CUL4A (physical association, anti bait coimmunoprecipitation) Piwko et al., EMBO J 2010
• IRef Intact Interaction: Complex of CUL4B-DDB1-CUL4A-CUL4B-DDB1-CUL4A (association, anti bait coimmunoprecipitation) Higa et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of ATM-CUL4A-LMNB1-DCAF6-DDB1-DCAF8 (physical association, tandem affinity purification) Hutchins et al., Science 2010
• IRef Intact Interaction: Complex of 23 proteins (association, anti tag coimmunoprecipitation) Alexandru et al., Cell 2008
• IRef Ophid Interaction: DDB1 — CUL4A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Chen et al., Mol Cell 2006 : Biochemical studies revealed that c-Abl promotes CUL-4A mediated DDB ubiquitination and degradation in a manner that does not require its tyrosine kinase activity both under normal growth conditions and following UV irradiation
Banks et al., Cell cycle (Georgetown, Tex.) 2006 : The isolated CUL4A complexes display potent and robust polyubiquitination activity towards p53 and this activity is dependent on L2DTL, PCNA, DDB1 , ROC1 and MDM2/HDM2