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EGFR — PRKAB1
Text-mined interactions from Literome
Liu et al., Cell cycle (Georgetown, Tex.) 2009
(Breast Neoplasms) :
At the molecular level, metformin increases
P-AMPK ,
reduces P-EGFR,
EGFR , P-MAPK, P-Src, cyclin D1 and cyclin E ( but not cyclin A or B, p27 or p21 ), and induces PARP cleavage in a dose- and time dependent manner
Jung et al., J Cell Physiol 2010
(Neoplasms) :
Quercetin suppresses HeLa cell viability via
AMPK induced HSP70 and
EGFR down-regulation ... Together, these results suggest that quercetin may have anti-tumor effects on HeLa cells via
AMPK induced HSP70 and down-regulation of
EGFR
He et al., Biochem Biophys Res Commun 2013
(Glioblastoma) :
Gambogic acid
induces EGFR degradation and Akt/mTORC1 inhibition through
AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells