◀ Back to PER1
PER1 — PER2
Pathways - manually collected, often from reviews:
-
KEGG Circadian rhythm - mammal:
Complex of CRY1-CRY2-CSNK1D-CSNK1E-PER1-PER2-PER3
→
Complex of ARNTL-CLOCK-NPAS2
(protein-protein, inhibition)
-
KEGG Circadian rhythm - mammal:
Complex of CRY1-CRY2-CSNK1D-CSNK1E-PER1-PER2-PER3
→
Complex of CRY1-CRY2-CSNK1D-CSNK1E-PER1-PER2-PER3
(protein-protein, state change)
-
KEGG Circadian rhythm - mammal:
PER1/PER2/PER3
→
PER1/PER2/PER3
(protein-protein, state change)
-
NCI Pathway Database Circadian rhythm pathway:
PER1-2 /NONO complex (PER1_PER2-NONO)
→
PER1-2 (PER1/PER2)
(modification, collaborate)
-
NCI Pathway Database Circadian rhythm pathway:
PER1-2 / CRY1-2 complex (PER1_PER2-CRY2_CRY1)
→
PER1-2 (PER1/PER2)
(modification, collaborate)
-
NCI Pathway Database Circadian rhythm pathway:
PER1-2 / CRY1-2 complex (PER1_PER2-CRY2_CRY1)
→
PER1/TIMELESS complex (TIMELESS-PER1)
(modification, activates)
-
NCI Pathway Database Circadian rhythm pathway:
PER1-2 / WDR5 complex (PER1_PER2-WDR5)
→
PER1-2 (PER1/PER2)
(modification, collaborate)
Brown et al., Science 2005*
-
NCI Pathway Database Circadian rhythm pathway:
PER1-2 / CRY1-2 complex (PER1_PER2-CRY2_CRY1)
→
PER1-2 / CRY1-2 / CK1 epsilon complex (PER1_PER2-CRY2_CRY1-CSNK1E)
(modification, collaborate)
-
WikiPathways Exercise-induced Circadian Regulation:
Complex of CRY2-CRY1-PER2-PER1
→
ARNTL/CLOCK
(inhibition)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sakamoto et al., Molecular vision 2006
:
Per1 and Per2 mRNA levels were rhythmic in saline injected and in KA-treated retinas, and
Per2 mRNA levels were significantly
reduced ( 20-50 % ) in KA-treated retinas
Ogawa et al., PloS one 2011
:
Indeed, only the Per2 promoter, but not
Per1 , was strongly
induced by both PER1 and
PER2 in the presence of CLOCK-BMAL1 in a luciferase reporter assay