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MAPK3 — PTK2B

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK3 → PTK2B (increases, PTK2B Activity, MAPK3 Activity) Blaukat et al., J Biol Chem 1999*
  Evidence: the Grb2/Sos complex connects Pyk2 to the activation of ERK, whereas adaptor proteins p130Cas and Crk link Pyk2 with the JNK pathway.

Text-mined interactions from Literome

Pandey et al., J Biol Chem 1999 : Overexpression of RAFTK leads to the activation of p38 MAPK ... We observe that the dominant negative mutant of MKK3 but not of MKK6, SEK1, or MEK1 inhibits RAFTK induced p38 MAPK activity
Kumar et al., J Biol Chem 1999 : Overexpression of RAFTK induces activation of c-Jun amino-terminal kinase ( also known as stress activated protein kinase ), mitogen activated protein kinase ( MAPK ), and p38 MAPK ... Furthermore, in contrast to the phosphatase-dead SHPTP1 C453S mutant, overexpression of wild-type SHPTP1 blocks interaction of RAFTK with the SH2-domain of c-Src and inhibits RAFTK mediated MAPK activation
Couty et al., Biol Cell 2004 (Disease Models, Animal...) : In in vitro systems, HHV-8-GPCR signals via multiple transduction pathways including, activation of phospholipase C and PKC, inhibition of adenylyl cyclase, activation of nuclear factor-kappaB ; activation PI 3-kinase, p42/44 MAPK and Akt/PKB, and activation of JNK/SAPK, p38 MAPK and RAFTK
Hatch et al., Blood 1998 (Leukemia, Monocytic, Acute) : Inhibition of RAFTK by a dominant negative kinase mutant reduced CSF-1/M-CSF induced MAPK activity