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GHR — STAT5A

Pathways - manually collected, often from reviews:

• BioCarta growth hormone signaling pathway: GH/GH R/GH R/JAK2/JAK2 complex (GHR-JAK2-GH1) → STAT5 (STAT5A/STAT5B) (modification, activates)
• Reactome Reaction: GHR → STAT5A (reaction) Behrmann et al., J Biol Chem 1997
• Reactome Reaction: GHR → STAT5A (indirect_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: GHR — STAT5A (in vivo) Xu et al., J Biol Chem 1996*
• IRef Ophid Interaction: GHR — STAT5A (aggregation, confirmational text mining) Xu et al., J Biol Chem 1996*
• IRef Ophid Interaction: GHR — STAT5A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Maamra et al., J Biol Chem 1999 : The GH antagonist, B2036, blocked Jak2-Stat5 mediated GHR signaling but was internalized with a similar time course to native GH
DiFedele et al., Gastroenterology 2005 (Carcinoma, Hepatocellular...) : GH resistance in experimental colitis is caused by down-regulation of GHR expression, thereby reducing GH-dependent STAT5 activation
Rowlinson et al., Nat Cell Biol 2008 : Mutations disabling this conformational change cause impairment of ERK but not JAK2 and STAT5 activation by the GHR in FDC-P1 cells
D'Mello et al., Inflamm Bowel Dis 2012 (Body Weight...) : Hepatic GHR abundance, GH induction of Stat5 tyrosine phosphorylation, and Igf-I mRNA expression were reduced in male card15-deficient mice with ileitis due to GM-CSF neutralization and NSAID exposure
Hansen et al., J Mol Endocrinol 1997 : The role of GH receptor tyrosine phosphorylation in Stat5 activation