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ELMO1 — RAC1

Pathways - manually collected, often from reviews:

• KEGG Chemokine signaling pathway: Complex of DOCK2-ELMO1 → RAC1/RAC2 (protein-protein, activation)
• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → DOCK1/ELMO1 complex (DOCK1-ELMO1) (modification, collaborate)
  Brugnera et al., Nat Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of RAC1 activity: ELMO1 (ELMO1) → RAC1/GDP complex (RAC1) (modification, activates) Sanui et al., Blood 2003*, Kunisaki et al., J Cell Biol 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of RAC1 activity: ELMO1 (ELMO1) → RAC1/GTP complex (RAC1) (modification, activates) Sanui et al., Blood 2003*, Kunisaki et al., J Cell Biol 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: RAC1/GDP complex (RAC1) → FAK/Src-Yes-Fyn/p130 CAS/CRK/DOCK1/ELMO1 complex (PTK2-YES1_SRC_FYN-BCAR1-CRK-DOCK1-ELMO1) (modification, collaborate)
  Cho et al., J Cell Biol 2002, Hsia et al., J Cell Biol 2003, Sharma et al., BMC cell biology 2008, Kiyokawa et al., Genes Dev 1998, Dolfi et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAC1/GDP complex (RAC1) → RhoG/GTP/ELMO1/DOCK1 complex (RHOG-ELMO1-DOCK1) (modification, collaborate)
  Katoh et al., Nature 2003
  Evidence: mutant phenotype, assay
• NCI Pathway Database Netrin-mediated signaling events: RAC1/GDP complex (RAC1) → netrin 1/DCC/DOCK1/ELMO1 complex (NTN1-DCC-DOCK1-ELMO1) (modification, collaborate)
  Grimsley et al., J Biol Chem 2004, Li et al., Nat Neurosci 2008
  Evidence: mutant phenotype, assay
• Reactome Reaction: ELMO1 → RAC1 (direct_complex) Janardhan et al., PLoS Biol 2004*
• Reactome Reaction: ELMO1 → RAC1 (reaction) Brugnera et al., Nat Cell Biol 2002, Janardhan et al., PLoS Biol 2004*, Lee et al., J Biol Chem 2007

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM ELMO1-DOCK1-RAC1 complex: ELMO1-DOCK1-RAC1 complex complex (DOCK1-ELMO1-RAC1) Brugnera et al., Nat Cell Biol 2002
• IRef Dip Interaction: Complex of DOCK2-RAC1-ELMO1 (anti tag coimmunoprecipitation) Janardhan et al., PLoS Biol 2004*
• IRef Intact Interaction: Complex of DOCK2-RAC1-ELMO1 (physical association, pull down) Lu et al., Curr Biol 2005*
• IRef Intact Interaction: Complex of 13 proteins (physical association, pull down) Lu et al., Curr Biol 2005*

Text-mined interactions from Literome

Brugnera et al., Nat Cell Biol 2002 : In cells, binding of Dock180 to Rac alone is insufficient for GTP loading, and a Dock180 ELMO1 interaction is required ... We can also detect a trimeric ELMO1 Dock180 Rac1 complex and ELMO augments the interaction between Dock180 and Rac ... We can also detect a trimeric ELMO1 Dock180 Rac1 complex and ELMO augments the interaction between Dock180 and Rac
Lu et al., Methods Enzymol 2006 : The best characterized is the Rac activation by the Dock180-ELMO complex
Hiramoto et al., Exp Cell Res 2006 : Dock4 formed a complex with ELMO, and expression of active RhoG induced translocation of the Dock4-ELMO complex from the cytoplasm to the plasma membrane and enhanced the Dock4- and ELMO dependent Rac1 activation and cell migration
Tosello-Trampont et al., Cell Death Differ 2007 : Although the role of ELMO : Dock180 in regulating Rac activation has been well defined, the function of CED-2/CrkII in this complex is less well understood
Yamaki et al., Exp Cell Res 2007 : However, RhoG induced suppression of anoikis was independent of the ELMO- and Dock180 mediated activation of Rac1
Komander et al., Mol Biol Cell 2008 : Significantly, although this does not affect DOCK180 GEF activity toward Rac in vivo, Rac signaling is impaired, implying additional roles for ELMO in mediating intracellular Rac signaling
Roppenser et al., J Cell Sci 2009 : RhoG and its downstream effector module Elmo/Dock180 controlled both Rac1 activation by Invasin and Rac1 deactivation by YopE
Lanoue et al., Mol Psychiatry 2013 : Regulation of dendrite morphogenesis by BAI3 involves activation of the RhoGTPase Rac1 and the binding to a functional ELMO1 , a critical Rac1 regulator
Fritsch et al., Cell 2013 (Fibrosis) : In fibroblasts, GPCRs couple to PI3K through Dock180/Elmo1 mediated RAC activation and subsequent interaction with p110ß